Look at the bodybuilders from the early 1950's. THAT's how big you can get naturally (maybe) with perfect diet, work-out, and genetics.
Lee Priest's whole face looks different from when he was a teen-ager. He is 5'-4" (or thereabouts) and weighs something shy of 300 lbs. YOU figure it out.
Without actually having video of him shooting his ass full of gear, I'd still have to say he's probably done everything under the sun.
-BigLittleTim