Why NOT to run T3

[OGPackin]

Hey bros, i got this post off of Animal's forum posted by Animal himself. Good info on why NOT to run T3.

OG

Now you see another reason why people are told to NOT take t3 with H or anything else. It increases SHBG! That being said, this little diddy also explains why somebody like me with low T levels and hypothyroid puts on muscle and/or retains it so well. BECAUSE MY SHBG IS LIKELY ALMOST ZERO!


Opposite effects of thyroid hormones on binding <a href="http://www.allsportsnutrition.com/listproducts.php?style=category&value=PROTEIN" target="_blank">protein</a>s for steroid hormones (sex hormone binding globulin and
corticosteroid binding globulin) in humans [published erratum appears in Eur J Endocrinol 1995 Sep;133(3):381
Author
Dumoulin SC; Perret BP; Bennet AP; Caron PJ
Address
Department of Endocrinology' CHU Rangueil' Toulouse' France.
Source

Eur J Endocrinol, 132(5):594 8 1995 May
Abstract
Sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) levels were evaluated in euthyroid
(N = 111)' hyper (N = 58) and hypothyroid (N = 38) men' in pre and postmenopausal women (study 1) and in
hyper (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or levothyroxine
therapy (study 2). The SHBG levels are increased in hyper and decreased in hypothyroid patients' whereas CBG
levels are increased in hypo and decreased in hyperthyroid patients. The SHBG levels are higher in women than in
men with similar thyroid status. Plasma SHBG levels are correlated positively whereas CBG levels are correlated
negatively with free thyroid hormone concentrations in men as well as women. In hypothyroid patients' SHBG
concentrations increased (p < 0.01) and CBG concentrations decreased (p < 0.01) during levothyroxine treatment. In
hyperthyroid patients' SHBG concentrations decreased (p < 0.01) and CBG concentrations increased (p < 0.01)

during antithyroid treatment. The SHBG and CBG concentrations in treated hypo and hyperthyroid patients were not
significantly different from those of euthyroid controls. Our data indicate that SHBG and CBG levels depend on thyroid
status. Corticosteroid binding globulin is an index of thyroid hormone action at the liver level whose changes are
opposite to those of SHBG in hyper and hypothyroidism.