Quote Originally Posted by davpet View Post
The package insert for Cytomel (T3) says that the half-life for T3 is 2.5 days and that it should be taken all at once.

Bodybuilding sites say that the half-life of T3 is 10 hours and that your dose should be split through out the day.

Who should you believe ?
well, obviously i would believe the pharmaceutical company. But heres where things differ:
Cytomel is for hypothyroidism, taken once a day because the dosage is only 25mcg. The dosing protocol for it probably says once a day because its similar to how the body produces T3.

The bodybuilding sites recommend spreading out the dosage because the amount consumed is generally not and HRT dose, but rather to increase metabolism to supraphysiological levels (which can be very dangerous). In an attempt to prevent a super high peak plasma level, such as one would experience if they took everything at once, the authors suggest spreading it out. That way you get a stable blood level rather than the 'roller-coaster' effect. Its safer to do it that way, but then again, high dosages of T3 arent really safe to begin with.