My girl friend runs t3 quite often at 1mcg per lb of body weight, that's what it takes to get her into the optimal range. but she goes 7 days on followed by 5 days off, then repeating this several times till the desired weight is lost. The key is to monitor her basal body temp...goto "testing your thyroid function" for instructions on how to do this. make sure to read "thyroid post cycle therapy" as well. There is no difference whether you are male or female when it comes to metabolic rate, peoples bodies burn the greatest amount of fat at a certain basal temp, which has nothing to do with saying women should take less. your aiming for a RT between 97.6 - 98.2 for optimal fat loss O'natural, with the aid of t3 it's closer to 98.2 - 98.8 deg F...if you go above 98.8 then decrease the dose slightly..if you stay below 98.0 then increase the dose slightly.