No, run it straight through. Every third week take 50mg of benadryl every night before bed and it will "up-regulate" your receptors so you can run clen for 6 weeks at a time. I have done it this way and the benadryl works. For doses.... start low.. maybe at 40mcg/day and go up slowly until you can handle the sides. Personally, I don't believe that anyone should use more than 80-100mcg/day, but some guys go really high... like 240mcg/day.