This post (it's by "Animal Mass") has been refuted many times here...
Writer
This post (it's by "Animal Mass") has been refuted many times here...
Anabolic Member
Yeah it makes you wonder where the author gets his info from as I cannot see any citations.Originally Posted by hooker
Anabolic Member
Yea making it sound like winstrol is good for tendons and bone joints, ask Buylongterm what he thinks of Winstrol's benefits for tendons and bone joints. I've read that test reduces callogen by more like 10%, not 50 to 80%, someone is just making this all up.
Anabolic Member
I havent used EQ but know guys that say their elbows and knees started hurting real bad when on EQ, to the contrary deca is widely known for soothing bone joints, deca even all but cured my knee bursitus so I can vouch for deca.
Junior Member
Title: Stimulation of collagen synthesis by the anabolic steroid stanozolol.
Researchers: Falanga V, Greenberg AS, Zhou L, Ochoa SM, Roberts AB, Falabella A, Yamaguchi Y; University of Miami School of Medicine, Department of Dermatology, Miami, Veterans Affairs Medical Center, Florida, USA.
Source: J Invest Dermatol 1998 Dec;111(6):1193-7
Summary: In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 micrograms per ml) had no effect on fibroblast replication and cell viability but enhanced collagen synthesis in a dose-dependent manner. Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels. There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta-1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta-1. These findings point to a novel mechanism of action of anabolic steroids.
Discussion: I must first acknowledge that the commonly held belief is that anabolic steroids predispose an athlete to tendon rupture. This conclusion is drawn from animal studies showing that some steroids produce a larger, stiffer tendon in rats and that these steroid-induced tendons "fail" before the tendons from the control animals. The term fail refers to the breaking point.
The interesting thing about the present study is that the steroid stanozolol (Winstrol) had a different effect than testosterone. If you are a regular reader of MESO-Rx you should be well aware that not all steroids act in the same manner. And that because of subtle differences in there molecular structure they are able to elicit different responses. For example, Deca seems to act primarily through the androgen receptor (AR) where as Dianabol has effects beyond those associated with the AR.
Because synthetic steroids have differ in their chemical properties it should not be surprising that testosterone did not have the same effect as Winstrol. Winstrol increased collagen synthesis as opposed to testosterone which did not in this study. Interpreting the results of this study are more difficult than simply describing them. Other researchers have suggested that steroids cause a rapid increase in protein synthesis within tendon fibroblasts which results in fibroids or fibrous nodules within the tendon (Michna,1988). These fibroids alter the mechanical properties of the tendon perhaps predisposing it to rupture. It is also noted that during short term use of steroids there is an alteration in the alignment of collagen fibers which may also lead to rupture. Interestingly these alterations in collagen metabolism are transient with markers of collagen turnover returning more or less to baseline after 3-4 weeks of steroid administration (Karpakka,1992). These same researchers noted that low dose anabolics effect primarily muscle collagenous tissue with tendon being effected only at higher doses (i.e. 5 times the therapeutic dose) which would more closely represent what is needed by bodybuilders to put on mass.
The question remains, does this mean that Winstrol will actually help prevent tendon injury or will it lead to bigger yet stiffer tendons prone to injury? It is difficult to take animal research and extrapolate the results to humans. Stanozolol is used therapeutically in humans to treat a variety of connective tissue and vascular disorders and its clinical effects suggest that it can modulate connective tissue breakdown in people. Despite being labeled as "ineffective" by many bodybuilders it is very popular among athletes. As with most hormones, dosage plays a role in what effects are seen, be they positive or negative. Hopefully future studies will shed light on the therapeutic effects of different steroids on tendons in humans.
References:
Michna H Appearance and ultrastructure of intranuclear crystalloids in tendon fibroblasts induced by an anabolic steroid hormone in the mouse. Acta Anat (Basel) 1988;133(3):247-50
Karpakka JA, Pesola MK, Takala TE. The effects of anabolic steroids on collagen synthesis in rat skeletal muscle and tendon. A preliminary report. Am J Sports Med 1992 May-Jun;20(3):262-6
Junior Member
Steroids May Improve Tendon Repair After Surgery
posted by FContact on atomicalmuscle
Steroids May Improve Tendon Repair After Surgery
Reuters Health
By Merritt McKinney
Thursday, July 1, 2004
NEW YORK (Reuters Health) - Anabolic steroids are against the rules for professional athletes, but preliminary research suggests that steroids may help repair a shoulder injury that affects many professional and weekend athletes.
In lab experiments using bioengineered tendons, researchers at the University of North Carolina at Chapel Hill found that tendons treated with an anabolic steroid were stronger than untreated tendons.
"In a highly experimental model, anabolic steroids do appear to improve the quality of rotator cuff tendon tissue," lead author Dr. Spero G. Karas told Reuters Health.
Most likely, steroids help by improving protein production in each tendon cell or by boosting the way tendon cells communicate with each other, Karas said.
But don't expect doctors to start prescribing anabolic steroids to people who have rotator cuff surgery any time soon. Karas cautioned that much more testing needs to be done.
"If enough testing can conclude that this treatment is effective, then of course we could attempt it in humans with difficult rotator cuff injuries," Karas said.
The rotator cuff is made up of the muscles and tendons that hold the upper arm bone to the shoulder. When the rotator cuff is injured, surgery may be performed to repair it. Unfortunately, healing after surgery is often incomplete and many people experience repeat rotator cuff injuries.
Anabolic steroids are known to build muscle mass and boost strength, so Karas and his colleagues set out to see whether steroids might improve rotator cuff healing.
The research involved bioengineered tendons developed by co-author Dr. Albert J. Banes. The researchers collected tendon samples from six people who were having rotator cuff surgery. Cells from these tendons were isolated and used to grow the bioengineered tendons.
Some of these tendons were treated with the anabolic steroid nandrolone decanoate, while others were not. Some tendons were also subjected to load testing, in which the tendons were stretched.
Tendons that had been treated with steroids and subjected to loading were stronger, denser and more elastic than other tendons, the researchers report in the American Journal of Sports Medicine. The steroid-treated tendons also had a more natural appearance than other tendons.
The research will not have an immediate impact on the treatment of rotator cuff injuries, but the research establishes a way to test the effect of mechanical stress and medications on tendon cells, Karas said.
"Any drug can be tested, but we chose an anabolic agent because of its successful background in treating patients with burns and other injuries," Karas said.
Another potential implication of the research, according to Karas, is that it "may permit us to manufacture a matrix of tissue that can be used to replace deficient human tissues."
Karas noted, "We are only in the embryonic phases of this work. We are a long way off, but the potential is exciting."
SOURCE: American Journal of Sports Medicine, June 2004
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