There's no prostate history in my family AT ALL and my doc says I'm fine, I just get weary with it. After 10 weeks I feel like I'm doing heavy military presses on a narrow seat, that's the kind of discomfort I feel, but I trust my doc and it goes away immediately when I stop injections and before the drugs are out of my system, kinda weird. BTW I like Big N's suggestion running it 2 weeks past the last EQ shot....