Some guys stay on estrogen suppression until the last day of the last injection then they stop all estrogen suppression drugs. Well you might have the highest testosterone levels of your cycle at that time and your anti-estrogen wears off allowing massive amounts of testosterone to convert to massive amounts of estrogen. So you might want to continue your anti-estrogens for 1 full week after last injection then it should be safe to discontinue the anti-estrogens.Originally Posted by BigJames