Just thought I would make an update. I just read a more recent report put out by Novaris on the use of Letrozole to treat breast cancer. As most of us know tamoxifen (nolva) is usually a first line of defense against breast cancer and then letro is used as a more powerful alternative if nolva is not working as well as expected.

Now, we have also been under the impression that running nolva and letro at the same time is not the best idea (as I stated in my original post). Nolvadex has been shown to reduce the blood plasma concentrations of letro by an average of 38%, enough to warrant a decision not to co-administer these drugs.

Now, in this latest research it was shown that blood plasma levels of letrozole WERE NOT diminished with co-administration of nolvadex...IF letrozole was administered directly after nolvadex.

I was very interested in this topic especially after the problem of gyno-reversal during PCT came about and this study was exactly what I was looking for. So although I have not put a tone of research into this and this is only ONE study, it does shed some light on the situation and give us reason to believe running them together, in cases where gyno has appeared during PCT, is not a bad idea.

So I will continue to research but that looks promising to me, so for those of you worrying about letro and nolva during PCT you could give it a try. Also since Letro dose signal LH and FSH production we can be assured it wont negatively affect PCT too much in terms of raising testosterone back up to par.