If you are doing Serono kits it wll be almost impossible to dose 4 iu. It will be 4.5 IU a day. Are you asking if you need to do slin with GH or how to do slin with GH? This was taken from a post Nandi12 made in regards to the question of should slin be used with GH. Thought it might be good reading for you.


You don't have to use insulin with GH but there are some reasons you might want to, depending on your goals.

GH has proven to be a much more effective lipolytic (fat mobilizing) drug than an anabolic drug. There are numerous studies showing that GH can reduce fat in obese people, but there is only one study that has shown GH can increase fat free mass in trained, athletic individuals. Critics of GH are also quick to claim that there is no proof that that mass increase reflected an increase in muscle mass; it could have been an increase in organ mass.

There is plenty of in vitro evidence, and evidence from protein kinetic studies in people, however, that both insulin and GH increase protein synthesis and inhibit protein breakdown. The latter studies look at the rates of appearance and disappearance of amino acids in the blood after GH or insulin administration. There is increased uptake into skeletal muscle, presumably reflecting protein synthesis.

There have been a few studies where GH and insulin have been infused together and the results are very interesting. The two combined have an additive effect on amino acid uptake, but GH seems to blunt insulins ability to inhibit amino acid release from cells. If true, this is saying that GH blunts insulin's ability to inhibit protein breakdown. The logical way to try to overcome this is to add more insulin.

This last observation may be related to GH's well known ability to
cause insulin resistance. This means that GH is interfering with insulin signalling. The reason bodybuilders use insulin is because insulin is required for amino acid uptake into cells. More insulin means more amino acid uptake and incorporation into muscle. So if GH interferes with insulin signalling, the effect can be overcome by adding exogenous insulin. In my mind this is the best reason to use GH and insulin together.

The downside is insulin promotes fat accumulation. So if you are primarily interested in cutting, GH alone is your best bet. If you want mass gains, you are better off combining insulin and GH. Of the two, insulin is probably the more anabolic, particularly when accompanied by high plasma levels of amino acids. ( High levels of amino acids are the most anabolic of all ). In fact, some researchers attribute GH's anabolic activity to insulin resistance: the body produces more insulin to overcome the diminished insulin signalling caused by GH, and this elevated insulin is what is responsible for any anabolic quality of GH. I think this is an extreme viewpoint, since IGF-1, which GH elevates, has been shown to both inhibit protein breakdown and promote protein synthesis.

So there is another way to look at this. Considering how anabolic and anticatabolic insulin is, maybe insulin should be your main anabolic supplement, and the GH is thrown in to offset some of insulin's fat promoting features. That is the way I like to look at it.

By the way, I should qualify the last remark about the anabolic and anticatabolic nature of insulin. The majority of studies show insulin exerts its positive effects on protein primarily by inhibiting protein breakdown. However, at larger doses insulin does promote protein synthesis, and as mentioned above, in the presence of amino acids it promotes synthesis as well. In the postabsorptive state when amino acid levels are not high, insulin is primarily anticatabolic.

So this provides another rationale for using insulin and GH together. If insulin mainly inhibits protein breakdown, and GH mainly increases protein synthesis, the two should combine synergistically.