You might want to do a search on accutane & ulcerative colitis. It dries your outsides up so think what it does to your gut. I took it for 5 months & ended up with UC. Went from 195 down to 127 in 4 months,almost died from taking this crap, also got arthritis. After doctors tried to waste every mucle in my body giving me predisones & othe BS drugs I put myself on test & HGH. I'm now at 187 & no signs of UC. Thank God for steriods & HGH. Just my thought, not saying everbody will get it, just hate to see anybody go thur what I did.