Well, again, you're not likely to get bitch tits with 4-Diol unless you've had them. That said, some have experienced itchy or puffy nipples which subsided when using an anti-Estrogen/Anti-aromatase---or after product cessation (if you experience this toward the middle, then obviously you should either stop, or add the anti-E---Ergopharm's 6OXO has already been used successfully for this).