IMO winny should be taken ED because of the short half-life. I believe its around 12 hrs. Doses should be split up throughout the day. I take a dose apprx. 30min. prior to lifting with 8oz. grapefruit juice. The juice aides with absorbtion. Second dose at bedtime. That way its in your system for 24hrs. You may get inconsistant results if its taken EOD. Make sure your taking some liver protectors along with it, i.e. milk thistle, glutamine, ALA, etc. Good luck.