Well personally I believe in taking a lot of it, biological sulfur is the third largest ingredient in the human body so it isn't going to hurt you. It's non-toxic and there are 0 side effects, it's as safe as water. I would suggest to use a load dose at first like 6-10 grams and maintain at 3-5 grams, I prefer the high end of both of those. Now one thing you should be aware of is that msm is a natural detoxifier, and if you have a lot of toxins in your body you may have the shits and some fatigue for a couple of days while they are being flushed out. If you have any questions about it feel free to PM me.