I take wellbutrin and Remeron right now. I can have one cup of coffee or a diet soda, but fat burners make me panic really bad. I didn't notice it from topical fat burners though ( I took Vyotech Ab-soultion) but Hydroxycut, Cytolean, Redline and other stimulants are big no-no's if you are on Wellbutrin IMO as they speed you up way to much. Sesathin you should be fine with, as its just EFA's which are actually good for mood disorders. Also you may want to start taking a good dose of fish oil daily, as I have heard many times it can improve mood safely in the long run. I take 4 caps, 3x a day and have seen more mood stability.