I am not sure about the progesterone issue nor your tren dosage, but Letro needs to be taken ED because of its half life and length of time it takes to stabilize in your blood (in some cases up to 60 days). I was having same problems as you (heck I have had sore nips even before I ever juiced) and after about a week of 2.5 mg letro a day the pain and itchiness stopped.