just sum a friend told me...he's pretty yoked up.. let me clear tha question up a lil... im going to take test 450 twice a week, 1cc wait a few days and go again.. He was sayN that 450mg in a single dose was to much. and that your body will only take in 250mg in a 24hour period... so iwas going to take half a cc evey two days, dude was juicen me up bout test flu. thanks for tha feed back!