I've been on 5iu/ed for six months. I started with 2iu/ed and increase 1iu every 10days. No swelling of the hands and headaches. I wanted to see if the stuff I had was real so I wen to 10iu for one day. Next day, fat fingers and puffy face. Yep, good stuff. Your body will acclimate to the HGH over time. If your HGH is not pure your body will create antibodies to fight the impurity. Either way, the sides should go away in a couple of weeks to a month.