Yes, I received my 1st shot 3 weeks ago. I just started HRT, the dr told me at the time he starts all his patients with the first shot at 100mg to see how they react to it then does blood work at 2 weeks to see what it brought their levels up to. From there he will determine how much he will increase the dosage and frequency of shots. I am going to push him for weekly injections based on some info about cypionate half life I've read about. He made it sound like most of his patients receive bi-weekly injections.