I think most of us here already knew this; but there are more and more research studies being conducted now on TRT in men and this one seems to be all but a mute point of contention anymore.
Testosterone and prostate cancer: what are the risks for middle-aged men?
Urol Clin North Am. 2011 May;38(2):119-24
Authors: Morgentaler A
With increased recognition of the benefits of testosterone (T) therapy for middle-aged men, there has been a concomitant reexamination of the historical fear that raising T will result in more prostate cancer (PCa). Studies have failed to show increased risk of PCa in men with higher serum T, and supraphysiologic T fails to increase prostate volume or prostate-specific antigen in healthy men. This apparent paradox is explained by the Saturation Model, which posits a finite capacity of androgen to stimulate PCa growth. Modern studies indicate no increased risk of PCa among men with serum T in the therapeutic range.
PMID: 21621078 [PubMed - indexed for MEDLINE]