Arimidex vs Letrozole vs Aromasin??

[Atomini]

I much prefer Aromasin over the other two common AIs (Arimidex and Letrozole), and I have mentioned this many times in different threads over the years. Arimidex and Letro don't do exactly the same thing as Aromasin. Aromasin is a suicidal Aromatase Inhibitor. This means that once it has bound to the aromatase enzyme, and thereby deactivated it, that enzyme remains bound to aromatase PERMANENTLY, rendering the enzyme inactive forever. Therefore, you do not end up with estrogen rebound.

The problem with Arimidex and Letro - being as strong as Letro is - is that they are only bound to the enzyme for a limited amount of time before they unbind and are metabolized by the body. This means that when not used carefully, you can end up with bad estrogen rebound if Letro or Arimidex is halted too suddenly, or without Nolvadex to keep breast tissue receptors occupied so that the incoming onslaught of estrogen will not flare up potential gyno.

Now, one may wonder "but if its suicidal, isn't that a bad thing for the body?". The answer is no. Aromasin may deactivate the aromatase enzyme permanently, but it doesn't stop your body from producing more aromatase. The enzymes that have been deactivated permanently will remain as such, but over time your body will slowly replenish its aromatase levels by producing more.

Other advantages Aromasin has over the other two AIs:

- Less harsh impact on blood lipid profiles (the inhibition and lowering of Estrogen in the body results in cholesterol profiles taking a turn for the worse - Aromasin has the least impact of all 3 AIs on this).
- Nolvadex does not lower blood plasma levels of Aromasin!!! Nolvadex, when used with Letrozole or Arimidex, has been proven to lower blood plasma levels of both compounds(1). When anti-gyno protocols are taken into consideration where the use of Nolvadex with an AI is concerned, this presents a big problem where Aromasin is the clear victor above all other AIs. When trying to combat gyno (or used for PCT), Aromasin and Nolvadex work flawlessly together.

REFERENCES:
1. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):85-91.

[warmouth]

I much prefer Aromasin over the other two common AIs (Arimidex and Letrozole), and I have mentioned this many times in different threads over the years. Arimidex and Letro don't do exactly the same thing as Aromasin. Aromasin is a suicidal Aromatase Inhibitor. This means that once it has bound to the aromatase enzyme, and thereby deactivated it, that enzyme remains bound to aromatase PERMANENTLY, rendering the enzyme inactive forever. Therefore, you do not end up with estrogen rebound.

The problem with Arimidex and Letro - being as strong as Letro is - is that they are only bound to the enzyme for a limited amount of time before they unbind and are metabolized by the body. This means that when not used carefully, you can end up with bad estrogen rebound if Letro or Arimidex is halted too suddenly, or without Nolvadex to keep breast tissue receptors occupied so that the incoming onslaught of estrogen will not flare up potential gyno.

Now, one may wonder "but if its suicidal, isn't that a bad thing for the body?". The answer is no. Aromasin may deactivate the aromatase enzyme permanently, but it doesn't stop your body from producing more aromatase. The enzymes that have been deactivated permanently will remain as such, but over time your body will slowly replenish its aromatase levels by producing more.

Other advantages Aromasin has over the other two AIs:

- Less harsh impact on blood lipid profiles (the inhibition and lowering of Estrogen in the body results in cholesterol profiles taking a turn for the worse - Aromasin has the least impact of all 3 AIs on this).
- Nolvadex does not lower blood plasma levels of Aromasin!!! Nolvadex, when used with Letrozole or Arimidex, has been proven to lower blood plasma levels of both compounds(1). When anti-gyno protocols are taken into consideration where the use of Nolvadex with an AI is concerned, this presents a big problem where Aromasin is the clear victor above all other AIs. When trying to combat gyno (or used for PCT), Aromasin and Nolvadex work flawlessly together.

REFERENCES:
1. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):85-91.

Awesome answer! And this is the reason I am going to start using Aromasin, without question! Now, since the use of aromasin and nolvadex lowers blood plasma levels, would it be safe to assume this could lower RBC due to the use of AAS, at least to a small percent?

[Atomini]

Awesome answer! And this is the reason I am going to start using Aromasin, without question! Now, since the use of aromasin and nolvadex lowers blood plasma levels, would it be safe to assume this could lower RBC due to the use of AAS, at least to a small percent?

I think you're misunderstanding my post.

I stated that the use of Arimidex or Letrozole with Nolvadex causes a drug interaction issue whereby Nolvadex will lower the blood plasma level of Arimidex/Letrozole. Nolvadex doesn't lower blood plasma. Nolvadex lowers blood plasma levels OF Arimidex and Letro when Nolvadex is used used together with either one.

[MotoLifter]

Very Nice Atomini. Factful, well writen and most importantly comprehensible. This may have changed my outlook on Aromasin somewhat. Again, nice work!!


Moto