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Thread: The use of Kisspeptin-10 as a PCT adjunct agent

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  1. #1
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    Jan 2013
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    Left sciatic nerve. Seems to be focused on my knee the worst. Disk hemorrhaged during a warm up deadlift where I made the mistake of trying to catch the bar when it slipped. Can say being home on an injury does not improve a bad marriage.

    As far as the number of shots it's not just the HPG axis restart but the LH and FSH surges for testicular recovery. Desensitization/suppression would be far more likely to occur from estrogen and/or progesterone. Which is why I'm taking 2.5mg letro/week plus .3mg pramipexole ED. I do not believe that desensitization would occur otherwise since Kisspeptin 54 surges occur naturally during puberty. I'm also taking forskolin to increase cAMP levels due to my age.

    What I have not seen in studies is a follow up where kisspeptin 10 has been discontinued for a longer washout period to see what changes occurred in testosterone, LH and FSH levels. In order to be effective as a PCT agent that's the real question.

    If I had used HCG during my cycle I don't think more than 4-5 shots would be needed. The reason why during PCT more than one shot might be helpful is on hormones left in the body. Even after waiting three days on a test prop/tren ace cycle how much tren is left or it's effect on a HPG axis restart is really an unknown. More than one shot acts as an insurance against possible suppression.
    Last edited by dvd; 02-03-2013 at 02:44 PM.

  2. #2
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    Quote Originally Posted by dvd View Post
    Left sciatic nerve. Seems to be focused on my knee the worst. Disk hemorrhaged during a warm up deadlift where I made the mistake of trying to catch the bar when it slipped. Can say being home on an injury does not improve a bad marriage.
    As far as the number of shots it's not just the HPG axis restart but the LH and FSH surges for testicular recovery. Desensitization/suppression would be far more likely to occur from estrogen and/or progesterone. Which is why I'm taking 2.5mg letro/week plus .3mg pramipexole ED. I do not believe that desensitization would occur otherwise since Kisspeptin 54 surges occur naturally during puberty. I'm also taking forskolin to increase cAMP levels due to my age.
    What I have not seen in studies is a follow up where kisspeptin 10 has been discontinued for a longer washout period to see what changes occurred in testosterone, LH and FSH levels. In order to be effective as a PCT agent that's the real question.
    If I had used HCG during my cycle I don't think more than 4-5 shots would be needed. The reason why during PCT more than one shot might be helpful is on hormones left in the body. Even after waiting three days on a test prop/tren ace cycle how much tren is left or it's effect on a HPG axis restart is really an unknown. More than one shot acts as an insurance against possible suppression.

    Desensitization from estrogen/progesterone doesnt happen, it only acts as a negative feedback preventing release of LH after stimulation of GnRH. Why are you taking letro during PCT, and Pramipexole? You shouldnt be using competitive inhibitors of aromatase ( esp one that potent, high chance of rebound when u stop) during PCT... And why the dopamine agonist still?


    The desensitization does occur quicker with Kiss-54 than Kiss-10, but it still does occur, Repeated administerations in lab experiments have shown the desensitizaiton with Kiss-54; alot more than Kiss-10...
    Are you injecting IM or IV?

    The problem with recovery isnt the pituitary most of the time, since LH can be stimulated and produced faster than Test can; the issue is the Leydig cells in the testes and the Intratesticular testosterone volume. Thats the reason for using HCG on cycle, the pituitary is gonna be shut down due to feedback but it can respond much quicker when it the feedback goes away.



    http://jcem.endojournals.org/content/96/8/E1228.long
    http://ajpendo.physiology.org/content/294/6/E1088.full

  3. #3
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    (Google: Kisspeptin neurons from mice to men: similarities and differences.)
    That paper coveres briefly some of the differences both between the different types of kisspeptin neurons and how they respond in different species.

  4. #4
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    I'll run the full panel in four weeks giving a two week washout period on anything used during the PCT.

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