I have used test cyp which is very simiular to test e. The first time I injected was this summer. I was not too happy about reaching around and trying to stick myself in the rear. I heard all the horror stories about quad injections but I liked the idea of a very straight forward injection where you can see everything and hold the needle very still. I can say that I like quad injections, I used a 25g 1" needle and I have never had a problem. if you sit the needle on the skin even the slightest pressure will pierce it and once it is in its like butter. Just go slow so you can feel if you are getting close to a nerve or going through a vein. I have gone through a few veins where you feel a little something but once you are to the other side you are good to go. I did end up with the needle sitting in the vein on my 4th shot. Very important to aspirate. I just pulled the needle out switched needles, pushed out some of the blood out, picked a new spot and was done. Make sure you follow all the correct procedures and you will actually look forward to them. Test Cyp never really hurts, rub the test in after for a minute or so and do some stretches like bending at the knees a few times. I only feel the oil in there right after for a bit. I have worked out legs many times the day after a quad injection. Good luck!