nothing during your off weeks. Keep an eye on your diet. For me, clen is an amp. I might lose 2 lbs a week natty then hit the clen and it starts peeling off like 5 lbs. (numbers are just for example) As for dosing start slow 20mcg with plenty of water and take it up slowly. With a healthy heart and if you pay attention to the sides you can run it up to 100mcg ONLY if you can handle the sides thats why I say go SLOW. Also supplement with Taurine I take 3 grams a day while on. You might get away with less. This will help prevent cramping.