wow that's a huge jump on your PSA, I bet your E2 is through the roof and that's part of what's screwing your PSA. what else were you taking? obviously your doc seems to be clueless here since he is not bothering doing more tests, or at least do E2 test and see if you need to be treated. this is why a recommended LowT.com to a friend of mine, is to save him the misery of the roller coaster and the danger of medicine malpractice.