I also want to chime in that lowering test dose alone can be an effective means toward controlling E2. As some of you know, I was started off on trt at too high a dose (200/wk). Technically my E2 at that level was in range, but it was right at the top and I definitely felt it. I was bloated, swollen ankles, and felt easily out of breath and just generally crappy. After a couple months on a lowered dose of 100/week all that has gone away and I feel great. I was initially paranoid I'd lose the positive effects of trt on a lower dose, but that was all in my head. The only changes have been for the better. I get another blood test next month so I won't know til then what numbers are, but I expect my E2 will be much lower in the range.