After stacking the winstrol I got hit with an E2 wave and was forced to cut from 75mg 2x to 60 first then 50mg... it wasn't an easy transition, and got cranky at times, even managed to broke my phone, but I do feel stable now. Like you said, yes gross variations can impact overall balance, as the brains adapts over time, and sudden fluctuations represent a challenge in homeostasis. E2 is a wonderful steroid, if affects both inhibitory and excitatory brain currents through different receptors, that means response to the hormone is heavily influenced by your individual make-up.
With nervouseness, it's no brainer that stimulants like caffeine, food intake and environmental factors will worsen it.
About E2, I get jittery mostly when I feel E2 on the high side. Drink some coffee, and tremors kick in, especially if I'm on a empty stomach. Heck, when I was on nebido (I'm a poor metabolizer so that resulted in cycle levels of Test, of course no AI ) even with menial tasks like preparing food I felt like my brain was on fire. Got bad insomnia at night, didn't eat much because of the bloating, and got pretty much unhealthy overall. But hey, if E2 is in check I can do just fine. When is on the low side, I start to get lethargic, foggy, and anxious.