E2's effect on BP is IMO the worst side.
Well, libido can be crushed too, but it depends on the individual.
Did an experiment long ago, with a high dose test regime.
I wasn't using an AI and was at about 750mg TE.
Then I felt some slight ED, and instead of just jumping on adex,
I tried banging in even more test.
This actually worked (as far as libido and ED), but only for a short time.
I then added in even more test prop, and it worked again.
DISCLAIMER: this is award winning prize in stupidity,
(But it was part of an experiment to learn the effects of E2 vs T)
Eventually I had to throw in an AI because of BP and bloat however.
(And lower the T dose)

Yup, estrogen has some complicated effects on the CNS.

I saw that pic Biz, I'd include an AI if I was you.
I don't know your overall BF, but if it's really bad just around the nips,
maybe try a SERM like nolva for some time.
Ofcourse, it isn't much point if BF is high overall.

You can get sensitive E2 labs here too, it's just seldom done.
(Or seldom if you go to your GP and not a specialist)
I'll take a look at my last BW where estrogen is measured an look.