Ephedrine Sulfate and Dangers of Overuse

[DocToxin8]

While the ECA stack has its merits,
I'm not sure I see any reason why one should up the aspirin dose (or caffeine) when one needs to increase ephedrine due to loss of sensitivity.
Many years ago when I used ephedrine I didn't take any set amount of caffeine or aspirin with it. I took a single dose aspirin in the morning with some caffeine,
and then just used pure l-ephedrine.
I ended up chugging down 600mg ephedrine a day, so I wasn't very responsible, but I didn't get hypertension either. (But I was young)
And I did have some scary experiences.

Thanks for sharing.

Like any stim people need to be careful with this.
Sound like you took a severe beating, happy you stopped.
That would eventually had lead to a stroke or a heart attacks.

[Obs]

While the ECA stack has its merits,
I'm not sure I see any reason why one should up the aspirin dose (or caffeine) when one needs to increase ephedrine due to loss of sensitivity.
Many years ago when I used ephedrine I didn't take any set amount of caffeine or aspirin with it. I took a single dose aspirin in the morning with some caffeine,
and then just used pure l-ephedrine.
I ended up chugging down 600mg ephedrine a day, so I wasn't very responsible, but I didn't get hypertension either. (But I was young)
And I did have some scary experiences.

Thanks for sharing.

Like any stim people need to be careful with this.
Sound like you took a severe beating, happy you stopped.
That would eventually had lead to a stroke or a heart attacks.

The ratios vary most recommend:1:10:3 E,C,A, or 1:10:5. The only purpose of the asprin is to prevent blood platelets from sticking together from the ephedrine as far as I know. That is a good point though. I wonder how necessary the asprin is beyond oh, say 500mg?

[DocToxin8]

The ratios vary most recommend:1:10:3 E,C,A, or 1:10:5. The only purpose of the asprin is to prevent blood platelets from sticking together from the ephedrine as far as I know. That is a good point though. I wonder how necessary the asprin is beyond oh, say 500mg?

You don't get any added benefit on platelets beyond 100mg aspirin.

Aspirin is an irreversible inhibitor of thromboxane A2 (an enzyme causing coagulation), so 75-100mg daily is enough to prevent this enzyme.
A higher dose of aspirin 500mg and up will also inhibit prostacyclin synthesis, which have beneficial effect on platelets.
This higher doses of aspirin actually negates the positive effect of small doses.
So higher doses of aspirin should be reserved for pain and inflammation IMO.

Aspirin is also a weak oxidative uncoupled.
That is, it has the same effect as 2,4-dintrophenol/DNP.
(Yet mildy) this is actually not necessarily unhealthy when it's mild.

It would require very high doses of aspirin to give DNP like effects,
but aspirin poisoning does cause fever, so.

But more to the point, high doses of aspirin = more sides, stomach issues, so on.

[Obs]

You don't get any added benefit on platelets beyond 100mg aspirin.

Aspirin is an irreversible inhibitor of thromboxane A2 (an enzyme causing coagulation), so 75-100mg daily is enough to prevent this enzyme.
A higher dose of aspirin 500mg and up will also inhibit prostacyclin synthesis, which have beneficial effect on platelets.
This higher doses of aspirin actually negates the positive effect of small doses.
So higher doses of aspirin should be reserved for pain and inflammation IMO.

Aspirin is also a weak oxidative uncoupled.
That is, it has the same effect as 2,4-dintrophenol/DNP.
(Yet mildy) this is actually not necessarily unhealthy when it's mild.

It would require very high doses of aspirin to give DNP like effects,
but aspirin poisoning does cause fever, so.

But more to the point, high doses of aspirin = more sides, stomach issues, so on.

When you put it like that... it should be an EC stack and take one aspirin per day.

[Richard Cabeza]

The ratios vary most recommend:1:10:3 E,C,A, or 1:10:5. The only purpose of the asprin is to prevent blood platelets from sticking together from the ephedrine as far as I know. That is a good point though. I wonder how necessary the asprin is beyond oh, say 500mg?

The aspirin actually has more benefits than that, it increases the half life of the caffeine and ephedrine making it stay in your system longer, it increases the thermogenic properties and also inhibits Prostaglandins synthesis. Prostaglandins inhibit the release of Noradrenalin. Just for reference the caffeine inhibits the activity of Adenosine. Adenosine also inhibits the release of Noradrenalin. These two substances act as blockers so your body will release more NA than usual, thus the ‘stimulant’ effect and thermogenics I'll post some studies in a bit. I just have to find them again

[GirlyGymRat]

The ratios vary most recommend:1:10:3 E,C,A, or 1:10:5. The only purpose of the asprin is to prevent blood platelets from sticking together from the ephedrine as far as I know. That is a good point though. I wonder how necessary the asprin is beyond oh, say 500mg?

Never used aspirin in the stack. Only ecy. Interesting.