If not running a blast, I have always been once a week and we are pushing 7 years now. I do not feel one bit different on day 2 as compared to day 7. My total T breaks 1300 36-48 hrs after pin to usually 400-450 on day 6 or 7. My E2 always runs low due to .5 of Anastrozole once per week. So I actually cut it out all together. That's truly how powerful it is.....I suspect a lot of people have much lower E2 than they realize from over doing it on the A.I.