Every a break from hcg?

[Youthful55guy]

I'm on trt and also take 500iu of hcg a week. My question is should you ever take a break from hcg? I know this small a dose won't cause desensitization, but I've heard many different opinions on if you should take a break. I would like to see a study if anyone can find one instead of going purely off advice. Thanks!

There are no studies or published information (that I know of) for or against this practice, and I personally do not buy into it. If there is published data, I'd like for someone to point me to it.

There is no reason at all to suspect that there is down regulation of the LH receptors in the testicles. Those who promote the theory of down regulation point to the biological need to pulse LH. This is true, but not for the reason they purport. It is well documented that GnRH receptors in the pituitary do down regulate, so the pulsatile nature of LH is indirectly related to the need for the hypothalamus to pulse GnRH to the pituitary to prevent down regulation of the GnRH receptors. BTW, I happened to do my master thesis on this subject.