FYI: to all reading this thread. As Bizzaro and I have discussed in other threads, you must be EXTREMELY careful when using exogenous progesterone (P4)in a male TRT protocol. And this goes for synthetic anabolic steroids with progestin-like activity that are often stacked by bodybuilders. We all know and understand that high E2 can cause gynecomastia, but it is much more potent in this regard when progesterone levels are elevated. I believe this is the root of the paranoia I see in so many threads in this and other forums of high E2. Yes, high E2 is not good, but it gets a much worse reputation because of bodybuilder abuse of anabolic steroids without understand what they are doing. In the quest for big muscles, they often layer (stack) several anabolic hormones on top of each other without knowing how they interact.
Some anabolic steroids also have progesterone like activity. If you stack these with high levels of testosterone and don't control the conversion of T to E2, you are ripe for beginning development of gynecomastia. If your prolactin levels get out of control, you are in for a SEVERE case of gynecomastia (e.g., lactation). This is exactly what happens during the 3rd trimester of pregnancy. The placenta is producing very high levels of both E2 and P4 and at the same time producing a hormone called Placental Lactogen, which has both prolactin and growth hormone activity.
There are currently 1 users browsing this thread. (0 members and 1 guests)