Oral mesterolone will have an hard time reaching the brain, where it would exert its benefits.

According to Bayer, oral bioavailability is as low as 3%. That means even with high dosages few mgs of the compound will reach the bloodstream, where it will easily bind to SHBG due to high affinity. Thus, an increase in free T is more likely to happen than AR activation by the molecule.

Only way around to have a consistent amount of proviron to enter the brain is the parental way, 100% bioavailability. A nice DHT flood that will surely do the job. There used to exist IM provi there have been studies done on it.