best way to explain it is to just compare a basic 200$ telescope you get to look at the stars (basic details), compared to an advanced telescope at nasa thats designed to look at details.
a womens estrogen covers a very large range (big numbers easy to see) , a mans estrogen in comparison is much smaller range (small numbers hard to see).. so being men's numbers are so small in comparison we need a much more precise test to dial in the accuracy.
having said that.. I've got regular E tests done and have been as low as 10 and as high as high as upper 200s. were those numbers totally accurate . no, but they gave me some sort of base line to go off of for a basic cycle..
IF I was trying to dial in medically prescribed TRT I would definitely get the sensitive essay test. but just running a basic cycle it at least gives you some ball park numbers (small telescope numbers
