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Thread: Tips for Clomid use.

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  1. #1
    Join Date
    Sep 2010
    Location
    England
    Posts
    234
    Hi Cyclon, please help me. My Doctor can't seem to get my Oestradiol right. Please can you advise? I cant do the microdosing as you mentioned for Exemestane, I dont want to drink alcohol every day due to previous issues. Please can you advise on the below 4 questions, but no microdosing just tablet doses.

    Current dosage:
    - 25mg Clomiphene 3 times a week, I should decrease this as my red blood cells + Haematocrit is high?
    - Exemestane quarter of a tablet 2 times a week. I should increase this to what? Not working at all.
    - Also, what can I do about my red blood cells and Haemotcrit? I normally give blood, hence why the Ferritin is lower than before? But this year I have not.
    - Does Enclomiphene convert to Oestradiol as much as Clomiphene?

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  2. #2
    Join Date
    Nov 2018
    Location
    AKA "Nice Guy Cy"
    Posts
    3,596
    Quote Originally Posted by manveer1 View Post
    Hi Cyclon, please help me. My Doctor can't seem to get my Oestradiol right. Please can you advise? I cant do the microdosing as you mentioned for Exemestane, I dont want to drink alcohol every day due to previous issues. Please can you advise on the below 4 questions, but no microdosing just tablet doses.

    Current dosage:
    - 25mg Clomiphene 3 times a week, I should decrease this as my red blood cells + Haematocrit is high?
    - Exemestane quarter of a tablet 2 times a week. I should increase this to what? Not working at all.
    - Also, what can I do about my red blood cells and Haemotcrit? I normally give blood, hence why the Ferritin is lower than before? But this year I have not.
    - Does Enclomiphene convert to Oestradiol as much as Clomiphene?
    Quick thoughts...

    Blood donation should help to get rbc and hcrit in line. Not sure what that does to MCHC, though.

    Microdosing doesn't have to involve liquor. You can use PEG (which may be the same thing?) Or maybe even water. You will want to dig around some on that.

    Alternatively, you might just up the dose on it to 1/4 every third day or similar. You don't need to bring estrogen down much if you aren't having negatives.

    Also as has been observed dozens of time before, clomid is not without issues that make it bleah in the long term. You can and should try going to 12.5mg 4 to 6 days a week.

    One last note: clomid does not "convert" to estrogen. It causes estrogenic sides in a couple of ways. First, by raising testosterone, aromatase does its thing and raises estrogen. Second, the zuclomiphene portion of clomid IS an estrogenic molecule. Hence the recommend for enclomiphene.

    Bonus: enclomiphene does NOT have the estrogenic sides associated with clomid, though as mentioned I never could get it quite right for me as HRT. It does still indirectly cause estrogen increase from aromatization, but does not have the zuclomiphene molecule.

    Peep my enclomiphene thread in the HRT sub for details

  3. #3
    Join Date
    Sep 2010
    Location
    England
    Posts
    234
    Quote Originally Posted by Cylon357 View Post
    Quick thoughts...

    Blood donation should help to get rbc and hcrit in line. Not sure what that does to MCHC, though.

    Microdosing doesn't have to involve liquor. You can use PEG (which may be the same thing?) Or maybe even water. You will want to dig around some on that.

    Alternatively, you might just up the dose on it to 1/4 every third day or similar. You don't need to bring estrogen down much if you aren't having negatives.

    Also as has been observed dozens of time before, clomid is not without issues that make it bleah in the long term. You can and should try going to 12.5mg 4 to 6 days a week.

    One last note: clomid does not "convert" to estrogen. It causes estrogenic sides in a couple of ways. First, by raising testosterone, aromatase does its thing and raises estrogen. Second, the zuclomiphene portion of clomid IS an estrogenic molecule. Hence the recommend for enclomiphene.

    Bonus: enclomiphene does NOT have the estrogenic sides associated with clomid, though as mentioned I never could get it quite right for me as HRT. It does still indirectly cause estrogen increase from aromatization, but does not have the zuclomiphene molecule.

    Peep my enclomiphene thread in the HRT sub for details
    Thanks so much again mate.

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