seriously bro... if you REALLY want to enjoy the keys do some diving on the reefs and some fishing during the day... those bars will be open when you get back... The first time I went I stayed plastered on Duval street the whole time... was fun but I didn't know what I was missing. My brother lives there so I've been back several times now. Also, if you like History take a trolly tour, its cheap and very interesting... Oh yeah, and Mallory Square is a must at Sunset!
http://www.mallorysquare.com/
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