Muscle - Saw an interesting show on igf 2 - effects on tumors as well as blood sugar levels (adverse). Should these also be concerns with igf 1 ? Whats the diff between the 2 ?
Disappointment* Known SCAMMER - Do Not Trust *
Muscle - Saw an interesting show on igf 2 - effects on tumors as well as blood sugar levels (adverse). Should these also be concerns with igf 1 ? Whats the diff between the 2 ?
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IGF-2 acts much like IGF-1, like both they mimic Insulin and I believe IGF-2 also acts on insulin receptor just like IFG-1. The main difference is that IGF-2 is a major growth factor in pregnancy as this is how I learned it. IGF-2 also has its own receptor (IGF2r) that has an antagonistic effect on IGF-2 directly. Additionally the IGF2R has a role in endosome formation and trans golgi extracellular protein modification, though I do not remember to what extent. If you remember as some proteins leave the ribosome they are transported to the Golgi apparatus and undergo post translational modifications for proteins that are destine for the cell membrane or secretion from the cell.Originally Posted by jimmyinkedup
There is a condition called Doege-Potter syndrome, which is basically an IGF-II producing tumor of non-islet cell origin.
http://meeting.chestjournal.org/cgi/...t/134/4/c17002
Last edited by MuscleScience; 04-08-2009 at 08:29 PM.
Snook~ AR Lounge Monitor
"Cutting off the nose to spite the face" is an expression used to describe a needlessly self-destructive over-reaction to a problem: "Don't cut off your nose to spite your face" is a warning against acting out of pique, or against pursuing revenge in a way that would damage oneself more than the source of one's anger
http://en.wikipedia.org/wiki/Cutting...spite_the_face
~AR-Elite-Hall of Famer~
Hmm, makes sense I never heard that one before.
Vitamin Enhanced Sociopathic Post Whore
question is... did you win? lol
Banned
MS, I read an article a very long time ago that went into a dissertation about how certain muscle groups can be primarily composed of white corpsecules (sp) and others red, and depending on which one it was the muscles may respond differently to different stimulus.
For ex. if it was 'white', then the group may respond better to lighter wieghts higher reps, and it primarily 'red', then higher wieght less reps. Something along those lines. And each person can have it vary in thier body. Legs may be red, while pecs white. Does any of this ring true?
~AR-Elite-Hall of Famer~
I think you are referring to the actual color that certain types of skeletal muscle look like. This is depended on a heme containing compound called myoglobin which binds O2 for aerobic metabolism. All skeletal muscle types contain myoglobin but type 1 muscle fibers contain the most, which gives it the red color. Type IIb has the lowest content thus appears white.
I wrote this earlier in the thread.
Great question, my undergrad was in biology and is a great degree to have.
There are three basic muscle types in the body. Smooth Muscle, Cardiac Muscle and Skeletal Muscle. In this conversation we are going to talk about Skeletal Muscle just for everyone's clarification that may be reading this.
Within Skeletal Muscle (SM) there are different subtypes of fibers. For the purpose of this discussion we will talk about the three most accepted subtypes. Slow Twitch, Fast Twitch type IIA and Type IIB. I must point out that some researchers have possibly identified addition subtypes which I will only briefly mention as not to confuse everyone because it is not completely agreed upon by all authors the last time I checked.
Type I (slow twitch):
Type I slow twitch muscle fibers (ST) are fibers that express high levels of aerobic enzymes relative to other types and are very dense in mitochondria. The muscles themselves have a very high capillary density to bring in additional blood supplies. ST fibers are resistant to fatiguing and can contract and stay contracted repeatedly without fatiguing to a point. The main energy pathway of ST fibers is that of aerobic means, due to the increased expression of aerobic enzymes. These fibers can produce energy under anaerobic conditions but do not have the capacity to do so verses other types of muscle fibers. These muscle fiber types are generally used in everyday activities and are for long duration lower intensity exercises such as walking or jogging.
Fast Twitch Fibers Two Types:
Type IIb Fast Glycolytic (FG):
FG fibers are a type of fast twitch fiber that produces energy almost exclusively via anaerobic means. (without oxygen) They fatigue very rapidly and produce a very fast and forceful contraction relative to that of ST fibers. They are very low in mitochondrial density and have low capillary density along with decreased expression of aerobic enzymes relative to that of ST fibers. These fibers are mainly involved in very short and forceful contractions such as jumping or throwing a baseball. These fibers can best be trained by plyometric exercises as well as relatively heavy weight lifting.
Type II A Fast Twitch Oxidative Glycolytic (FOG):
FOG muscle fibers are a kind of hybrid fiber type between FG fibers and ST fibers. They display characteristics of both fiber types in that they can use both aerobic and anaerobic means to produce energy. FOG fibers can contract fast and forcefully just like FG fibers do but they also have built in fatigue resistant properties that ST fibers have. This is achieved by having more mitochondria and aerobic enzymes along with a higher capillary density in the muscle compared to FG fibers. These fibers are postulated to have the ability with training to morph into either ST or FG fibers. Meaning that with specific training such as in long distance running, that a FOG fiber can adapt and mimic to an extent the properties of ST fibers. These fibers will start to act more like a ST fiber than that of a normal Fast Twitch type of fiber and vice versa.
Additional Fiber Types:
In 2003 a paper authored by Spangenburg and Booth, proposed that there was an additional fast twitch fiber type called Type IIx. This is described as a fiber type between that of Type IIa and type IIb. Just to confuse everyone Type IIx use to be a alternate nomenclature for Type IIb fibers. The reason I bring it up at all is that depending on the text book and author this fiber type may or may not appear or be taught. Although Spangenburg and Booth are not the only ones to describe this potential new fiber type, their paper is the most commonly cited one in the literature. Just in case anyone is doing research at home or has learned it different in exercise physiology class.
References:
Essentials of Strength Training & Conditioning by Thomas R. Baechle, S Roger W. Earle,. Second Edition
Human Kinetics (2000)
Molecular regulation of individual skeletal muscle fibre types
E. E. Spangenburg and F. W. Booth (2003)
Acta Physiologica Scandinavica
Volume 178 Issue 4, Pages 413 - 424
Last edited by MuscleScience; 04-08-2009 at 10:42 PM.
"3 stars and a sun"
MS! any recommended sets and reps, for chest, arms, shoulder, back and legs?
bulking point of view.
Thanks!!!
~AR-Elite-Hall of Famer~
Yeah it is somewhere in this thread, someone asked me the same question and I broke it down to specific muscle groups. Let me dig in here and find it for you.
OK found it. Look at post 371 and 395, I believe they are on page 10 of this thread. Hope that helps???
Last edited by MuscleScience; 04-08-2009 at 09:26 PM.
"3 stars and a sun"
How many times you do your abs a week? thanks!
~AR-Elite-Hall of Famer~
2-3 times, at the most. But in my own exercise programs I do a lot of exercise that engage my abdominals with about every exercise I do. I like to train more for functionality.
Last edited by MuscleScience; 04-08-2009 at 10:37 PM.
"3 stars and a sun"
Thanks! MS....
Productive Member
Does your body stop synthesizing protein during a workout? Is it beneficial to consume a menial (say 20g) of protein pre-workout?
Member
What is the difference between l-glutamine and glutamine peptides and their effect on the body?
~AR-Elite-Hall of Famer~
No there is a constant recycling of proteins that goes on during exercise or normal physiology. Its just the proportion of protein degradation to protein synthesis. Its also relative to the types of proteins because during exercise there are some proteins that actually increase in the muscle cells. For arguments sake I will reserve my first statement to talk about structural and contractile proteins.
There is conflicting evidence about the effect of Pre-workout consumption of protein and protein sparing during exercise or increase in post workout protein synthesis. My take on the subject is if it doesnt upset your stomach to take it before working out, it certainly will not hinder your gains.
~AR-Elite-Hall of Famer~
L-glutamine refers to a free unbound amino acid. Where as glutamine peptide is basically glutamine strung together with peptide bonds. It is probably better know as wheat gluten hydrolysate. These are very pure forms of amino acids and are used in microbiology a lot to grow bacterial cultures with particular nutritional requirements.
I dont know of any reason why it would be any better than L Glutamine, in order for amino acids to be absorbed by the intestines they have to be in single amino form. Meaning they cant be in polypeptide arrangement. The only other thing that I can think of is how they are charged when they are broken into single aminos. Or that the glutamine peptide is just a more pure substance, no fill or other contaminates?
Banned
BTW thanks for the answer to my question MS. I see it what was meant by the article I read now. They tried to make it look different to press the agenda, but this makes since the way you explained it.
Anabolic Member
1,3 dimethylamylamine
what do you know about the stuff? makes me feel amazing but makes my heart feel like its in a vice.
~AR-Elite-Hall of Famer~
Not really a lot, I know its is suppose to be the replacement for ephedra. If thats the case then its basically a CNS stimulant.
Sorry I couldnt tell you more.
Member
I am having trouble putting thickness on my biceps. My peaks are good, I just want more width. What to do?
~AR-Elite-Hall of Famer~
Just put on more mass, you really cant shape a muscle. Its is already set by your genetics.
Member
Musclescience,You might remember I asked you a question regarding a medical issue I have.I asked in your blog.
Just in case you can't remember off the top of your head it goes like this.As an infant I had 3/4 or more of my colon removed.I have recently read that the intestines are involved in creating certain vitamins and maybe protiens.What I was wondering is do you know if my lack of a portion of my colon can affect my absorbtion of minerals, protiens , vitamins ect. Will I have to take in more to compensate or anything? Any help you can offer will be greatly appreciated.Thanks in advance.
~AR-Elite-Hall of Famer~
Really most of the food stuff (chyme) absorption is taken care of in the first few feet of the small intestines. The Colon reabsorbs whatever water and salts that is left in the food stuff. Basically the Colon holds and further processes waste before it is excreted out.Musclescience,You might remember I asked you a question regarding a medical issue I have.I asked in your blog.
Just in case you can't remember off the top of your head it goes like this.As an infant I had 3/4 or more of my colon removed.I have recently read that the intestines are involved in creating certain vitamins and maybe protiens.What I was wondering is do you know if my lack of a portion of my colon can affect my absorbtion of minerals, protiens , vitamins ect. Will I have to take in more to compensate or anything? Any help you can offer will be greatly appreciated.Thanks in advance.
Member
So your saying the only thing I am not getting is water (which makes life rather more annoying), the vast majority of the nutriants I eat will be absorbed by my body!Thank for putting my mind at ease.And thanks for the quick response.
"Born to lose, Dying to win"
I want more deff in my bi-s. they are big and strong but not really defined.
suggestions?
~AR-Elite-Hall of Famer~
Just have to drop some BF.
~AR-Elite-Hall of Famer~
No I am not saying that your body is not getting enough water. 90% of the water left in the food stuff has already been reabsorbed. The Colon is really only a holding tube if you will.So your saying the only thing I am not getting is water (which makes life rather more annoying), the vast majority of the nutriants I eat will be absorbed by my body!Thank for putting my mind at ease.And thanks for the quick response.
"Born to lose, Dying to win"
Cool. Im thinking of more questions brb
Member
No you picked me up wrong.Trust me I know I am getting enough water, what I ment was that the only thing I am eating/drinking that is not getting absorbed is the water.I understand what you are getting at.Still I would give pretty much anything to have a working colon,you don't know what you have until its gone.
~AR-Elite-Hall of Famer~
I guess that is true, the bastards took my tonsils when I was five. I have wondered what life would have been like if I still had them.
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Dont hurt yourself think to hard....
Member
Not realy the same thing.I guess that is true, the bastards took my tonsils when I was five. I have wondered what life would have been like if I still had them.
~AR-Elite-Hall of Famer~
True but they went through my rectum to get them.....Not realy the same thing.
"Born to lose, Dying to win"
LOL OK. I Already asked around about my Joint pain, But Why when I lift heavy (350lbs bench or any other very heavy set) Does it feel like I was hit by a Mac truck at the end of my workout?
Member
Are you sure that it was a medical profesional and not an uncle that you were told not to be alone with that performed that procedure,it doesn't sound right to me.True but they went through my rectum to get them.....
~AR-Elite-Hall of Famer~
Come to think of it, that does sound a bit odd.....Are you sure that it was a medical profesional and not an uncle that you were told not to be alone with that performed that procedure,it doesn't sound right to me.
~AR-Elite-Hall of Famer~
Do you mean like pain as in injury, or more like just extreme fatigue?
"Born to lose, Dying to win"
Fatigue, Sort of like my skeleton hurts I guess. Just feels like wow!!!! Duno how to explain really
~AR-Elite-Hall of Famer~
I think I know what your talking about. There was a guy that did research on how bones bend and deform during normal physical activities. I for the life of me cant think of his name. A lot of his work was originally with MVA's and skeletal fractures. A accident scene investigator would know who I am talking about if we have any on here. Anyway, bones deform normally to cope with normal stresses. Since long bones are tubular in nature (hollow) they are able to handle more stress. Basically a tubular structure that is hollow is stronger than a solid structure. I am sure BrokenBricks on here would be happy to explain the physics behind it because he deals with trauma a lot and is a physics nerd (joke BB).
Which leads me to bone deformity and apparent pain. There is a outer connective tissue structure called the periosteum. The Periosteum is the only part of the bone that can sense pain. I believe the endosteum (inner layer of the hollow bone) also has a role in pain sensation but I am not 100% sure on that. I will look it up later when I get back home from my travels.
When this periosteum gets inflammed, damaged, compressed or pathologically altered it will cause some pain. It is thought that under heavy loads that the bone deforms enough to the outer limits of its normal range and can cause pain. Also the process of remodeling the bone after heavy activity could also be a source of pain do to the chemical and inflammatory processes involved in normal bone remodeling.
Last edited by MuscleScience; 04-25-2009 at 12:32 PM.
"Born to lose, Dying to win"
Wow You may have hit it on the Head, Please Get back to me if you find anything more out.
I once had some forearm pain and did an X-ray of my Forearm, The Dr Noticed a slite bend in the bone. Not too noticable but there. I took 4 days off from lifting, did another Xray and it was not on that bend anymore. The Human Body is interesting to say the least.
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