CyoGenX now available (Product info/write up in here)
CyoGenX
There are two major hormones involved in building muscle and burning fat: Testosterone and Estrogen. They are both essential for multiple functions in the body, and neither can be dismissed when trying to build a muscular physique.
However, as many steroid users have found out, Testosterone converts to estrogen through the Aromatase enzyme… and while some estrogen is a good thing (is in fact, necessary) for building muscle and burning fat, too much is a bad thing. Estrogen can cause that watery “bloated” look and prevent you from looking muscular and ripped; on the other side of the coin, it can aid in building muscle, and keeping you healthy. Lowering estrogen too much with Anti-estrogenic drugs, as many steroid users have also found out, can cause a host of problems. The problem is to get all of the good effects of estrogen, while keeping the bad effects away.
The solution is CyoGenX.
CyoGenX is the first natural estrogen control formula that combines three ingredients to work in unison to produce all of estrogen’s positive effects, while actually lowering estrogen at the same time. It’s not the estrogen we necessarily want, but rather, its positive effects.
The first ingredient in CyoGenX is Procyanidin. Procyanidin is a natural Aromatase inhibitor, meaning it prevents Aromatase from converting Testosterone into Estrogen. It does this by binding on to the enzyme and preventing it from doing its job.
Procyanidin:
• Inhibits the Aromatase Enzyme (prevents testosterone from converting to estrogen at the genetic level, preventing both transcription and expression of Aromatase) [1-4]
• Acts similarly to Letrozole (a prescription Aromatase Inhibitor), and can destroy breast tumor tissue (gynecomastia) [1]
• Has anabolic properties (Inhibits the Glucocorticoid Receptor, thus allowing more muscle to be built)[4]
• Has Anti-Hypertensive properties [5]
• Improves Cognitive Function [5]
• Lowers LDL Cholesterol [6]
• Is a strong Anti-Oxidant (stronger than vitamin C or E) [6]
The second ingredient in CyoGenX is Resveratrol. This chemical is known to be one of the factors present in Red Wine and Dark Chocolate which is responsible for the so-called “French Paradox”. It has been added to CyoGenX for it’s ability to act as an Estrogen Antagonist/Agonist, giving all of the benefits of estrogen while still helping to lower overall estrogen levels in the body.
Resveratrol:
• Is a mixed estrogen receptor Agonist/Antagonist [7]
• Acts similarly to Nolvadex (a prescription Selective Estrogen Receptor Modulator) [7]
• Acts Similarly to both Arimidex (a competitive Aromatase Inhibitor) as well as Aromasin (a noncompetitive Aromatase Inhibitor) [8]
• Is Anti-Arthritic [9-10]
• Is Cardioprotective [11-12]
• Has anti-inflamatory properties [13-15]
• Aids in Fat loss [16-17]
• Increases LH and FSH [18]
• Protects the liver [19-20]
• Is an Anti-Viral [15, 21-22]
• Protects against prostate cancer [23-28]
The final ingredient in CyoGenX is Urtica Dioica. Urtica Dioica is an anti-estrogen derived from the stinging nettle plant.
Urtica Dioica:
• Is a potent Aromatase Inhibitor [29]
• Acts similarly to Proviron (a prescription anabolic steroid) in binding to Sex Hormone Binding Globulin, thus making more testosterone “free” and biologically active [30-31]
• Can reduce size of Benign Prostate growth [30]
• Improves HDL/LDL cholesterol ratio [32-33]
Until now, the problem with most anti-estrogens was that they lowered estrogen but caused almost as many problems as they solved. Lowering estrogen can cause immune dysfunction, loss of bone mineral content and joint integrity, cardiac issues, cognitive problems, bad cholesterol, and many other side effects. It will even raise natural LH levels, which will in turn raise testosterone levels for the natural athlete!
Clearly, CyoGenX is the best estrogen control formula ever designed for the natural athlete.
But what about the steroid assisted athlete?
Well, since CyoGenX lowers estrogen but at the same time actually fights against common steroid side effects instead of causing them it will prevent against both bloating and gynecomastia… but will fight virtually every other negative side effect from anabolic steroid use also! Even those taking highly toxic oral steroids will benefit from the liver protecting effects found in CyoGenX. The anti-inflamatory properties of CyoGenX will help recovery from lifting heavy weights, and the SHBG lowering properties of it will allow more anabolic hormones (natural or unnatural) to remain free and biologically active. It’ll act as a supercharger for anyone on steroids, but at the same time keep them healthy and strong!
CyoGenX is a must have supplement for those looking to control their estrogen levels while at the same time not lose any of estrogen’s beneficial properties…and for the steroid using athlete, it’s twice as necessary because it will prevent virtually all of the side effects from steroids!
CyoGenX….the last estrogen control formula you’ll ever need.
References:
1. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun 1;66(11):5960-7.
2. Suppression of Estrogen biosynthesis by procyanidin dimmers in red wine and grape seeds. Cancer Res. 2003 Dec 1;63(23):8516-22.
3. Suppression of aromatase (estrogen synthetase) by red wine phytochemicals. Breast Cancer Res. Treat., 67: 133-146, 2001
4. Modulation of aromatase gene expression by grape seed extract. Ikuko Kijima, et al. City of Hope, Durante, CA.
5. Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R771-5.
6. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin Nutr. 2006 Jul;84(1):252-62.Am J Clin Nutr. 2006 Jul;84(1):252-62.
7. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta.Endocrinology. 2000 Oct;141(10):3657-67.
8. The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells. Toxicol Sci. 2006 Jul;92(1):71-7. Epub 2006 Apr 11.
9. Effects of resveratrol in inflammatory arthritis.Inflammation. 2007 Apr;30(1-2):1-6.
10. [Inhibitory effect of resveratrol on the proliferation of synoviocytes in rheumatoid arthritis and its mechanism in vitro] Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Aug;31(4):528-33. Chinese.
11. Resveratrol ameliorates experimental autoimmune myocarditis. Circ J. 2007 Mar;71(3):397-404
12. Resveratrol Increases Vascular Oxidative Stress Resistance.Am J Physiol Heart Circ Physiol. 2007 Jan 12; [Epub ahead of print]
13. [Biological effects of resveratrol and other constituents of wine] Ceska Slov Farm. 2003 Nov;52(6):272-81. Review. Czech.
14. Polyphenolic phytochemicals versus non-steroidal anti-inflammatory drugs: which are better cancer chemopreventive agents? J Chemother. 2004 Nov;16 Suppl 4:3-6. Review.
15. Biological effects of resveratrol. Antioxid Redox Signal. 2001 Dec;3(6):1041-64. Review.
16. Borra MT, Smith BC, Denu JM. "Mechanism of human SIRT1 activation by resveratrol." J Biol Chem. 2005 Apr 29;280(17):17187-95.
17. Picard F, et al. "Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma." Nature. 2004 Jun 17;429(6993):771-6.
18. Juan ME, et al. "trans-Resveratrol, a natural antioxidant from grapes, Increases sperm output in healthy rats." J Nutr. 2005 Apr;135(4):757-60.
19. Kasdallah-Grissa A, et al. "Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats." Alcohol Alcohol. 2006 May-Jun;41(3):236-9
20. Sener G, et al. "Protective effects of resveratrol against acetaminophen-induced toxicity in mice." Hepatol Res. 2006 Apr 1; E-Published Ahead of Print
21. Effect of resveratrol on herpes simplex virus vaginal infection in the mouse. Antiviral Res. 2005 Sep;67(3):155-62.
22. 3,4',5-Trihydroxy-trans-stilbene (resveratrol) inhibits human cyt*****lovirus replication and virus-induced cellular signaling. Antiviral Res. 2004 Aug;63(2):85-95.
23. Yoo KM, et al. "Potent Inhibitory Effects of Resveratrol Derivatives on Progression of Prostate Cancer Cells." Arch Pharm (Weinheim). 2006 Apr 18;339(5):238-241
24. Jones SB, et al. "Resveratrol-induced gene expression profiles in human prostate cancer cells." Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604.
25. Scifo C, et al. "Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells." Oncol Res. 2004;14(9):415-26.
26. Kim YA, et al. "Antiproliferative effect of resveratrol in human prostate carcinoma cells." J Med Food. 2003 Winter;6(4):273-80.
27. Stewart JR, Artime MC, O'Brian CA. "Resveratrol: a candidate nutritional substance for prostate cancer prevention." J Nutr. 2003 Jul;133(7 Suppl):2440S-2443S.
28. Ratan HL, et al. "Resveratrol — a prostate cancer chemopreventive agent?" Urol Oncol. 2002 Nov-Dec;7(6):223-7.
29. Aromatase Inhibitors from Urtica dioica roots. Planta Med. 1995 Apr;61(2):138-140.
30. The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes.Planta Med. 1995 Feb;61(1):31-2.
31. Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).Planta Med. 1997 Dec;63(6):529-32.
32. Antihypercholesterolaemic and antioxidant activity assessment of some plants used as remedy in Turkish folk medicine. J Ethnopharmacol. 2006 Oct 11;107(3):418-23. Epub 2006 Apr 15.
33. Effect of Urtica dioica extract intake upon blood lipid profile in the rats. Fitoterapia. 2006 Apr;77(3):183-8. Epub 2006 Feb 23.
