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Thread: Anti psychotics and increased prolactin.

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    edmundo22 is offline Associate Member
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    Anti psychotics and increased prolactin.

    Hey guy's.

    Iv been lifting weights for the past two years all the while taking seroqual, I didn't know it increased prolactin till recently, I used to be very well built my whole life without weights and without proper diet have naturally high testosterone . I attributed my loss of muscle to been 35 but now I'm thinking the seroqual to be a bigger factor, I'm eating all the right food have a calorie surplus and a solid work out routine but still no gains or progress but have lost 40 lb of fat, I don't know exactly how much seroqual increases prolactin it's not meant to be the worst psych med for this. I was switched to rispadone recently and literally had zero strength or energy so I stopped it it's meant to be the worst for prolactin, I'm due to start clozapine but if it's wrecking my ability to grow muscle I might not, I don't know if clozapine increases prolactin it's different from all other psych meds but I can't find any exact literature on it, if anyone knows anything about it please let me know.

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    GearHeaded's Avatar
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    I don't know much about psych drugs at all . BUT I do know there are things that you can take that do not necessarily lower your Prolactin, but will blunt prolactin receptors and may thus be of benefit to you. but I'm saying that assuming your an AAS user and why your on a steroid forum
    Last edited by GearHeaded; 10-04-2018 at 01:35 PM.

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    edmundo22 is offline Associate Member
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    Not an AAS user, I already had an account on here so I just use it for general workout advice.

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    GearHeaded's Avatar
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    Quote Originally Posted by edmundo22 View Post
    Not an AAS user, I already had an account on here so I just use it for general workout advice.
    well darn it I was just about to prescribe you some steroids to take.

    oh well.. so how is your nutrition, do you get in plenty of red meat ?

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    edmundo22 is offline Associate Member
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    Which steroid ?, At dinner it's either 300 grams of chicken or salmon / beef / pork / lamb, I don't want to take testosterone just want my natural test at its best but wouldn't say no to a steroid for reducing prolactin, is it carber?, cuz that's kinda pricey for a long term solution.

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    All Anti-psychotics have side effects, clozapine especially that is why it is only usually prescribed after two other anti-psychotics have failed to have a therapeutic benefit.

    Clozapine is incredibly efficient at causing metabolic syndrome, Type 2 diabetes and cardiovascular problems. I could provide you with journal articles on this if you like, I wrote a paper on this not long ago. If you don't mind me asking what is your diagnosis? You appear quite insightful and your cognitive functioning seems Ok... so what's the justification for the clozapine?

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    edmundo22 is offline Associate Member
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    Hey Socio.
    you know your stuff, my diagnosis is major depression and paranoid psychosis, I got both from getting addicted to huffing leaded gasoline as a kid. Iv ran through a bunch of anti psych meds over the past 10 years none have really helped, it's only cuz I suggested clozapine to my doc that there finally putting me on it, it's meant to be the best and most effective, I can deal with drooling at night, feeling drowsy but don't want fatigue / lack of strength. Iv read clozapine works differently from all the rest in that it doesn't affect dopamine receptors which I think is the cause of increased prolactin, I'm also looking into nuerogenic drugs to heal whatever damage I have in my brain, currently taking NSI 189 and looking into ISRIB next, I workout mostly cause it helps depression just don't want to be held back due to psych meds hindering my progress.

    My doc says it does increase prolactin, it could be minimal but I can't find anything online that gives exact figures, what's metabolic syndrome?, getting fat?

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    SocioMachiavelli's Avatar
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    Quote Originally Posted by edmundo22 View Post
    Hey Socio.
    you know your stuff, my diagnosis is major depression and paranoid psychosis, I got both from getting addicted to huffing leaded gasoline as a kid. Iv ran through a bunch of anti psych meds over the past 10 years none have really helped, it's only cuz I suggested clozapine to my doc that there finally putting me on it, it's meant to be the best and most effective, I can deal with drooling at night, feeling drowsy but don't want fatigue / lack of strength. Iv read clozapine works differently from all the rest in that it doesn't affect dopamine receptors which I think is the cause of increased prolactin, I'm also looking into nuerogenic drugs to heal whatever damage I have in my brain, currently taking NSI 189 and looking into ISRIB next, I workout mostly cause it helps depression just don't want to be held back due to psych meds hindering my progress.

    My doc says it does increase prolactin, it could be minimal but I can't find anything online that gives exact figures, what's metabolic syndrome?, getting fat?
    Cardiovascular exercise can cause neurogenesis, to combat the depression running would be better than lifting.... but both would be best.

    What are you like when you are off of your meds? I'm sure that you are aware that you have to be slowly titrated onto the clozapine and you should be having both pre and post clozapine observations.... This consists of BP/Heart rate/temp/resp rate etc. I am interested how this will be facilitated outside of a hospital, Unless I am mistaken and you are in one. You will also require routine blood tests to check for agranulocytosis, also if you are smoker this can inhibit the concentration levels of the drug in your system... So if you do smoke and decide to stop talk to the doc first.

    Clozapine can be incredibly effective at treating resistant psychotic symptoms, however on average men with schizophrenia die on average 18.6 years younger than those without it... A lot of this is down to lifestyle choice but also due to iatrogenic illness (illness caused by the psych meds). If you could find a way of making it work without the clozapine I would definitely do that, I appreciate you have spent ten years trying to find the right meds... but I'd advise keep looking and take up running.

    You can also be prescribed procyclidine to combat the extra pyramidal side effects such as excess salivation etc

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    Testlolblast is offline Junior Member
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    Don't take clozapine: it's bad for white blood cells. Usually haldol is first line. Well abilify stabilizes dopaminergetic system. Abilify + haldol is a good choice not to get too high prolactin levels, but it's better to rely on a doctor's choice. There is also bromocriptine by the way.

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    Testlolblast is offline Junior Member
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    By the way, it's a proven fact that inapropiate steroid use can cause halucinations, psychosis, etc. I would not advise you to take anything more than testosterone as being on TRT. Good luck!

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    SocioMachiavelli's Avatar
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    Quote Originally Posted by Testlolblast View Post
    By the way, it's a proven fact that inapropiate steroid use can cause halucinations, psychosis, etc. I would not advise you to take anything more than testosterone as being on TRT. Good luck!
    That's a very strong assertion to make. Could you point me in the direction of the evidence for this?

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    edmundo22 is offline Associate Member
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    Thanks for the reply's.
    I switched to vaping 5 years back and already do cardio, had more bloods done today and starting clozapine next few days, there's an outpatient hospital that will be doing daily tests and monitoring everything, already been on a ton of psych meds that haven't worked hence the clozapine which is meant to be the most effective.

    Back to why I made this most, if it's not prolactin killing my gains it has to be the cardio, lol I don't know shit, I start the gym with 10 minutes on the treadmill flat out at 13 on the dial don't know if it's km/hr or what but it's fast and intense, Iv recently read your meant to space out six hours between both and definitely not right before lifting.

    So is this where Iv been going wrong?, If I switch to running on my rest days will I start getting gains?

  13. #13
    SocioMachiavelli's Avatar
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    I'd certainly recommend separating the cardio from the weight lifting. To maximise hypertrophy you want to be able to lift heavily and with good form. If you hit the treadmill first and are running like you stole something you're going to be depleting the muscles glycogen etc before lifting. You want to have all your energy etc saved for the lifting.

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