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Thread: Adequan

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    DoubleL's Avatar
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    Adequan

    I've searched the forums for any results. The only thing I can find are dead threads where someone has said they were going to try Adequan and started or whatever but never followed up with any results. I've heard all the rants about how its awesome and it works. I want to hear it from someone who has used it. So if anyone has used Adequan please let me know how it went for you.

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    Did a search and this is what I found "Help Your Horse Reach Full Potential" sounds great now what the fuk is it ?

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    I wrote an article on it, and posted it on www.*****************.com , in the Educational Forum, under the title "(PSEG) Adequan"....check it out there...

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    Quote Originally Posted by hooker
    I wrote an article on it, and posted it on www.*****************.com , in the Educational Forum, under the title "(PSEG) Adequan"....check it out there...
    Thanks Hooker !!!

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    It's for joints and such. I have a torn labrum in my shoulder. The labrum is the cartilage in the shoulder. Keeps the shoulder from dislocating and such. Adequan is a polysulfated glycosaminoglycan. I dunno the science talk, but maybe that makes sense to some of you. It promotes fluid in the joints, relieves pain and disability of damaged joints, stops degeneration of cartilage as well as helps in rebuilding damaged cartilage. This is what I've gathered. If any of this info is incorrect i'm sorry. This is what I have found. Some claim that its also anabolic , but I haven't found any substantial evidence that would lead me to believe this. I know what it is supposed to do. I wanna know what it does. If anyone has any info on it let me know. Thanks.

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    Ok.....I gave it my all. Little did I know someone probably much smarter than me posted the info while I was writing my .02 cents worth. I tried.......

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    Quote Originally Posted by hooker
    I wrote an article on it, and posted it on www.*****************.com , in the Educational Forum, under the title "(PSEG) Adequan"....check it out there...
    Hooker have your tried this stuff ?

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    Nope.

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    Do you know anyone who has?

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    After reading your article and reading the fda report I see the reason people are saying it's anabolic . I see the fact that it possibly will prevent more damage to my shoulder. Maybe I missed this part, but will it help "fix" my shoulder in any way? Some of that scientific stuff is over my head. I'm a Poly Sci major, not a chemist. Those articles and such were very helpful, hooker. Thanks. Any more info you can scrape up would be greatly appreciated.

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    WLlewellyn is offline New Member
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    One of my dogs gets AQ injections, and can tell you, FWIW, that this drug does wonders for him. He has orthopedic problems, and it makes a night and day difference. He is like a normal dog while on it, running, jumping around and playing with other dogs, and limps and sleeps all the time when it isn’t given.

    It is a strong anti-inflammatory though, which means it is going to block the necessary conversion of arachidonic acid to anabolic prostaglandins. As such, it will prob inhibit muscle growth. I wouldn't advise taking any AI drug when bodybuilding if it can be avoided.

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    Quote Originally Posted by DoubleL
    I've searched the forums for any results. The only thing I can find are dead threads where someone has said they were going to try Adequan and started or whatever but never followed up with any results. I've heard all the rants about how its awesome and it works. I want to hear it from someone who has used it. So if anyone has used Adequan please let me know how it went for you.
    sorry bro here ya go......it's working for me

    http://forums.steroid.com/showthread...36#post1476336

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    Quote Originally Posted by WLlewellyn
    It is a strong anti-inflammatory though, which means it is going to block the necessary conversion of arachidonic acid to anabolic prostaglandins. As such, it will prob inhibit muscle growth.
    I thought the same thing, and logically, it should; but actually, as a side effect IM administration of 500mgs E4D for 12 weeks of PSGAG (adequan) , the mean test subject showed roughly a 13.5% increase in bodyweight, unless I'm mis-reading the data or missing something in the equation. I suppose the subjects could have just been in really bad shape (for horses), because they are injured....and gained the weight as a result of being more active and eating more, since they are recovering from injury by using this drug (where presumably they'd lost some weight from muscle atrophy).

    Reference:

    http://www.fda.gov/cvm/efoi/section2/140901111189.html

  14. #14
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    I am STILL looking to get my hands on some, I have searched high and low, offered big money to some and still nothing. I feel like a crack-whore ready to give blow jobs to feed my craving! Seriously I have tried many methods on obtaining adequan and NO luck........

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    I feel like a crack-whore ready to give blow jobs to feed my craving!

    And thats why I love this board....

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    I had rot. cuff surgery...you won't need the adequan if they're just o-scoping you. It'll help, of course, though.

    I also had surgery on the other shoulder (full invasive, for a loose tendon which couldn't keep my shoulder in the socket), and that was 100x worse.

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    Quote Originally Posted by WLlewellyn
    One of my dogs gets AQ injections, and can tell you, FWIW, that this drug does wonders for him. He has orthopedic problems, and it makes a night and day difference. He is like a normal dog while on it, running, jumping around and playing with other dogs, and limps and sleeps all the time when it isn’t given.

    It is a strong anti-inflammatory though, which means it is going to block the necessary conversion of arachidonic acid to anabolic prostaglandins. As such, it will prob inhibit muscle growth. I wouldn't advise taking any AI drug when bodybuilding if it can be avoided.
    I started it when I started my current EQ and Test cycle I have gained 25lbs.....

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    Well I have been to the doctors, he says it is bicipital tendinitis, where the bicep tendon connects into the shoulder it is tearing away from the bone. He gave me anti-inflamatory. I go to a specialist this week . Adequan WOULD help in this situation.

    Someone has to have a hook up......

  19. #19
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    Tlr?

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    Sodium Hyaluronate? Never heard of it.....I am going to research it a bit.

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    After doin' more research I found that it was legal at one time in Europe and sold under the name Arteparon. It was taken off the market. I haven't been able to pinpoint why yet. Still reading thru lots of medical journals. I've asked two doctors about it (glycosaminoglycan polysulfate), both of whom are shoulder/sports injury specialists. They had not a clue. Just wanted to talk about how glucosamine and chondroitin might help but no garuntees. The problem with cartilage is the fact that it doesnt bleed leaving no natural healing process. Cartilage sucks my a$s.

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    Quote Originally Posted by MMA
    adequan is better for degenerative joint diseases than traumatic ones, but still useful. the injury forum at AB has some threads on it.
    I would like to read those threads. What is the AB board? Thanks.

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    Why isnt there anything like this for humans?

    From all the articles it seems to be pretty safe as far as toxicity but can anyone think of a reason why it would not be safe for human consumption?

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    thebrakes is offline Associate Member
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    um...you can get adequan from lambriar. $50 for 5mL. and i have no idea what the difference is between dog and horse varieties.

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    i have been researching this as well. it sounds really good and could help me with my shoulders. i found a sweet deal online. 4 vials at 5ml for $140. it's for horses, but how safe is it for us? i know a couple of guys tried it on this board, would love to hear about their experience.

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    Yo thebrakes, I just checked that site.....you need a script. How did you get yours? Or anyone else thatgot some?
    Last edited by phwSSJ; 01-24-2005 at 10:52 AM.

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    Quote Originally Posted by soo2bhuge
    i have been researching this as well. it sounds really good and could help me with my shoulders. i found a sweet deal online. 4 vials at 5ml for $140. it's for horses, but how safe is it for us? i know a couple of guys tried it on this board, would love to hear about their experience.
    I took the canine and it helped a bunch. I had dislocated one shoulder and torn my rotator cuff on the other and after 8 weeks they both feel great. You know how everyone is always saying Deca is great for Joint pain and it is but this stuff blows Deca away. When you stop the deca the pain comes back because it didn't fix the problem, when you stop taking Adequan like I did 4 weeks ago the pain doesn't come back because while you were taking it your were helping speed up the healing process and breaks the destructive cycle in your joints.

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    Quote Originally Posted by D-END
    I took the canine and it helped a bunch. I had dislocated one shoulder and torn my rotator cuff on the other and after 8 weeks they both feel great. You know how everyone is always saying Deca is great for Joint pain and it is but this stuff blows Deca away. When you stop the deca the pain comes back because it didn't fix the problem, when you stop taking Adequan like I did 4 weeks ago the pain doesn't come back because while you were taking it your were helping speed up the healing process and breaks the destructive cycle in your joints.
    awesome. good to know man.

  29. #29
    phwSSJ's Avatar
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    Here is some interesting info I found.

    "Luitpold
    Osteoarthritis Drug
    Polysulfated Glycosaminoglycan Solution 100 mg/mL

    Adequan Canine is recommended for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints and following surgical procedures involving a joint.

    Active Ingredients
    Each mL of ADEQUAN® Canine contains 100 mg of PSGAG, 0.9% v/v benzyl alcohol as a preservative, and water for injection q.s. to 1 mL. Sodium hydroxide and/or hydrochloric acid added when necessary to adjust pH.

    Indications
    ADEQUAN® Canine is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.

    Pharmacology
    The active ingredient in ADEQUAN® Canine is polysulfated glycosaminoglycan (PSGAG). Polysulfated glycosaminoglycan is a semi-synthetic glycosaminoglycan prepared by extracting glycosaminoglycans (GAGs) from bovine tracheal cartilage. GAGs are polysaccharides composed of repeating disaccharide units. The GAG present in PSGAG is principally chondroitin sulfate containing 3 to 4 sulfate esters per disaccharide unit. The molecular weight for PSGAG used in the manufacture of ADEQUAN® is 3,000 to 15,000 Daltons.
    The specific mechanism of action of ADEQUAN® in canine joints is not known. PSGAG is characterized as a "disease modifying osteoarthritis drug". Experiments conducted in vitro have shown PSGAG to inhibit certain catabolic enzymes which have increased activity in inflamed joints, and to enhance the activity of some anabolic enzymes. For example, PSGAG has been shown to significantly inhibit serine proteinases. Serine proteinases have been demonstrated to play a role in the Interleukin-1 mediated degradation of cartilage proteoglycans and collagen. PSGAG is reported to be an inhibitor of Prostaglandin E2 (PGE2) synthesis. PGE2 has been shown to increase the loss of proteoglycan from cartilage. PSGAG has been reported to inhibit some catabolic enzymes such as elastase, stromelysin, metalloproteases, cathepsin B1, and hyaluronidases, which degrade collagen, proteoglycans, and Hyaluronic acid in degenerative joint disease. Anabolic effects studied include ability to stimulate the synthesis of protein, collagen, proteoglycans, and Hyaluronic acid in various cells and tissues in vitro. Cultured human and rabbit chondrocytes have shown increased synthesis of proteoglycan and Hyaluronic acid in the presence of PSGAG. PSGAGs have shown a specific potentiating effect on Hyaluronic acid synthesis by synovial membrane cells in vitro.
    Absorption, distribution, metabolism, and excretion of PSGAG following intramuscular injection have been studied in several species, including rats, rabbits, humans, horses and dogs.
    Studies in rabbits showed maximum blood concentrations of PSGAG following IM injection were reached between 20 to 40 minutes following injection, and that the drug was distributed to all tissues studied, including Articular cartilage, synovial fluid, adrenals, thyroid, peritoneal fluid, lungs, eyes, spinal cord, kidneys, brain, liver, spleen, bone marrow, skin, and heart.
    Following intramuscular injection of PSGAG in humans, the drug was found to be bound to serum proteins. PSGAG binds to both albumin and chi- and beta-globulins and the extent of the binding is suggested to be 30 to 40%. Therefore, the drug may be present in both bound and free form in the bloodstream. Because of its relatively low molecular weight, the synovial membrane is not a significant barrier to distribution of PSGAG from the bloodstream to the synovial fluid. Distribution from the synovial fluid to the cartilage takes place by diffusion. In the Articular cartilage the drug is deposited into the cartilage matrix.
    Serum and synovial fluid distribution curves of PSGAG have been studied in dogs and appear similar to those found in humans and rabbits.
    In rabbits, metabolism of PSGAG is reported to take place in the liver, spleen, and bone marrow. Metabolism may also occur in the kidneys. PSGAG administered intramuscularly and not protein bound or bound to other tissues is excreted primarily via the kidneys, with a small proportion excreted in the feces.

    Dosage and Administration
    The recommended dose of ADEQUAN® Canine is 2 mg/lb body weight (.02 mL/lb, or 1 mL per 50 lb), by intramuscular injection only, twice weekly for up to 4 weeks (maximum of 8 injections). Do not exceed the recommended dose or therapeutic regimen. Do not mix ADEQUAN® Canine with other drugs or solvents.

    Contraindications
    Do not use in dogs showing hypersensitivity to PSGAG. PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders.

    Precautions
    Store at room temperature 18°-25°C (64°-77°F).
    Use with caution in dogs with renal or hepatic impairment.

    Caution
    Federal law restricts this drug to use by or on the order of a licensed veterinarian.

    Warning
    Keep this and all medications out of reach of children.

    Side Effects
    In the clinical efficacy trial, 24 dogs were treated with ADEQUAN® Canine twice weekly for 4 weeks. Possible adverse reactions were reported after 2.1% of the injections. These included transient pain at the injection site (1 incident), transient diarrhea (1 incident each in 2 dogs), and abnormal bleeding (1 incident). These effects were mild and self-limiting and did not require interruption of therapy. To report suspected adverse reactions or for a copy of the Material Safety Data Sheet for this product, contact Luitpold Pharmaceuticals, Inc. at 1-800-458-0163.

    Toxicology
    In a subacute toxicity study, 32 adult beagle dogs (4 males and 4 females per treatment group) received either 0.9% saline solution or PSGAG at a dose of 5 mg, 15 mg, or 50 mg per kg of body weight (approximately 2.3, 6.8, or 22.7 mg/lb), via intramuscular injection twice weekly for 13 weeks. PSGAG doses represent approximately 1X, 3X, and 10X the recommended dosage of 2 mg/lb, and more than 3 times the recommended 4-week duration of treatment. Necropsies were performed 24 hours after the final treatment. During week 12, one dog in the 50 mg/kg dosage group developed a large hematoma at the injection site which necessitated euthanasia. No other mortalities occurred during the treatment period. Statistically significant changes in the 50 mg/kg group included increased prothrombin time, reduced platelet count, an increase in ALT and cholesterol, and increased liver and kidney weights. Increased cholesterol and kidney weights were also noted in the 15 mg/kg group. Microscopic lesions were noted in the liver (Kupffer cells containing eosinophilic foamy cytoplasm), kidneys (swollen, foamy cells in the proximal convoluted tubules), and lymph nodes (macrophages with eosinophilic foamy cytoplasm) in the 15 mg/kg and 50 mg/kg groups. Intramuscular inflammation, hemorrhage, and degeneration were seen in all 3 PSGAG treated groups; the incidence and severity appeared dose related.

    Trial Data
    Efficacy of ADEQUAN® Canine was demonstrated in two studies. A laboratory study using radio labeled PSGAG established distribution of PSGAG into canine serum and synovial fluid following a single intramuscular injection of 2 mg/lb. A clinical field trial was conducted in dogs diagnosed with radio graphically-confirmed traumatic and/or degenerative joint disease of 1 or 2 joints. Joints evaluated included hips, stifles, shoulders, hocks and elbows. Fifty-one dogs were randomly assigned to receive either ADEQUAN® Canine at 2 mg/lb of body weight or 0.9% saline. Both treatments were administered by intramuscular injection twice weekly for 4 weeks (8 injections total). Investigators administering treatment and evaluating the dogs were unaware of the treatment assignment. A total of 71 limbs in 51 dogs were evaluated. Of these, 35 limbs in 24 dogs were in the ADEQUAN® Canine treated group. Each lame limb was scored for lameness at a walk, lameness at a trot, pain, range of motion, and functional disability. The scores for the individual parameters were combined to determine a total orthopedic score. At the end of the treatment period, dogs treated with ADEQUAN® Canine showed a statistically significant improvement in range of motion and total orthopedic score over placebo treated control dogs.
    Studies to establish the safety of ADEQUAN® Canine in breeding, pregnant, or lactating dogs have not been conducted. "
    (http://www.abitatrace.com/AdequanCa.aspx)

    Looks like we will be safe at the low doses hooker recomended.
    Last edited by phwSSJ; 01-24-2005 at 01:52 PM.

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