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Thread: Clen worth it??

  1. #1
    Machdiesel's Avatar
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    Clen worth it??

    clens gonna cost me about 500 a month, n this is at minimal dosage. Is it worht the money, or will i see same results with E/C/A stack, i mean if its no comparison ill spend the money, but if its gonna be similar ill save 400 bucs n go with ephdrine n caffine?

  2. #2
    Drkodiak1's Avatar
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    I think clen is an awesome drug but if its gonna cost you 500 dollars a month i would say screw it.. When you say minimal dosage how much r u refering to....I was able to handle 240mcgs per day and saw excellent result and ate whatever i wanted and ran stairs 3 times a week

  3. #3
    niXon)('s Avatar
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    WTF are you thinking spending that much on clen ? I got mine for 50 bucks. last me a looooong time. but research and you'll see most people say eca and clen have almost same effect. personally i think clen does better

  4. #4
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    Good Lord Thats A **** Load Of $$$$$$$ For Clen ...you Should Be Payin 10% Of That

  5. #5
    Machdiesel's Avatar
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    i saw 200 mcg for 60 bucs( i didnt really look hard, but once i saw this price i stopped researching prices, seeing as im gonna start taking 60 a day, which is the advised for first time users) so im guessing the price is a rip, if ne one can shoot me a pm for good sites to get it from or watever id really appreciate it

  6. #6
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    how does clen come to 500 a month....

  7. #7
    Machdiesel's Avatar
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    like i said i have been researching clen for about a week, i just did a search online to get an idea of how much it owuld be in it immediatly turned me off, im gonna ask around with some of my buddies, im sure they can get it but looked online to get an idea, guess i looked at some booty ass webpage

  8. #8
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    bro there is NO WAY IN HE!! clen can run you that much, if so someone is laughing all the way to the bank
    ~HOP

  9. #9
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    ok I GET IT, IM AN IDIOT!!!!! lol i just looked online to get an idea of what its gonna run me n that was the price i found on some pages, so what should i get it for, how much$$$ i think im gonna run it for a month, im not really over weight, im 6'1 n 195 lbs, im pretty skinny but have a gut, ive been working out for about a month n look better everywhere except my stomach(ESP LOWER) n havnt lost ne weight, i figure one month should be sufficent with cardio 4 times a week, abs 3 times a week, n weight taining 4 times a week, n following the cutting sticky

  10. #10
    Jimbo2 is offline New Member
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    The $60 should be for a bottle of 100 tabs and that would be a good brand name thru a source.

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    bro you say you are pretty skinny but you have a gut. why not just clean up your diet and hit the treadmill. save the clen for a rainy day
    ~HOP

  12. #12
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    i have a very clean diet, and do exercise, i do cardio for 40 mins 4 times a week, abs 3 times a week, n weight train 4 times a week. Ive been on this for a month n only lost like 2 ounds n am looking better EVERYWHERE else but my stomach, so its frustrating, i dont want a miracle drug im putting in the time n effort, but wanna se results from my hard work, u know wat i mean, im getting to the point where im lek this **** isnt worth it

  13. #13
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    Quote Originally Posted by Jimbo2
    The $60 should be for a bottle of 100 tabs and that would be a good brand name thru a source.
    how much mcg per tab???

  14. #14
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    sorry double posted

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    Dozerd is offline Junior Member
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    Quote Originally Posted by Machdiesel
    i saw 200 mcg for 60 bucs( i didnt really look hard, but once i saw this price i stopped researching prices, seeing as im gonna start taking 60 a day, which is the advised for first time users) so im guessing the price is a rip, if ne one can shoot me a pm for good sites to get it from or watever id really appreciate it
    did it also say 30ml after the 200mcg meaning you would have 6000mcgs?

  16. #16
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    Quote Originally Posted by houseofpain
    bro you say you are pretty skinny but you have a gut. why not just clean up your diet and hit the treadmill. save the clen for a rainy day
    ~HOP
    I agree with HOP....Save it for later....

  17. #17
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    Quote Originally Posted by Machdiesel
    i have a very clean diet, and do exercise, i do cardio for 40 mins 4 times a week, abs 3 times a week, n weight train 4 times a week. Ive been on this for a month n only lost like 2 ounds n am looking better EVERYWHERE else but my stomach, so its frustrating, i dont want a miracle drug im putting in the time n effort, but wanna se results from my hard work, u know wat i mean, im getting to the point where im lek this **** isnt worth it
    good to hear that you are on top of that diet and such. good luck losing that stubborn stomach fat bro
    ~HOP

  18. #18
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    Quote Originally Posted by Machdiesel
    i saw 200 mcg for 60 bucs( i didnt really look hard, but once i saw this price i stopped researching prices, seeing as im gonna start taking 60 a day, which is the advised for first time users) so im guessing the price is a rip, if ne one can shoot me a pm for good sites to get it from or watever id really appreciate it
    Bro click the top right banner and your wish is granted.

  19. #19
    Machdiesel's Avatar
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    is clen like ur first cycle, where as u will see your best gains( in this case ur best losses) on your first time use?? also been readin gup on clen, half say 3 weeks on 3 weeks of, hooks clen article states this to be false, im not going against what he said, but most articels seem to believe in 3 on 3 off, is this outdated and proven to be wrong?

  20. #20
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    Here Bro read this and you should have a good idea. This was stolen form HOOKERS steroid profiles.

    Clenbuterol




    Clenbuterol (Clen ) is a selective beta-2 agonist/antagonist and a bronchodilator. What this means, is that it stimulates your beta-2 receptors. Of great importance, is that Clenbuterol is a selective beta-2 agonist (because it works selectively on the beta-2-andrenergic-receptors), right? The thing is, Clenbuterol is selective...like hitting a tack (the tack being your beta-2 receptors)with a small hammer (the hammer being the Clen)...thus, it hits the beta-2 receptors selectively. Sorry if that seems repetitious, but it’s very important to understand that fact before we move on. Since clenbuterol has very little beta-1 stimulating ability, it has the ability to reduce certain kinds of airway obstruction without much in the way of cardiovascular effect (more about that later), and this is why it is used as an asthma medication.

    So what exactly dose a stimulant like Clen (or Ephedrine) do when it stimulates those Beta Receptors? Well, it serves to increase your body temperature a bit by increasing heat production in the Mitochondria, increase your basal metabolic rate, and decrease your appetite (1). This partly explains how Beta-2 agonists directly stimulate fat cells and increase lypolysis (fat-loss)(1)(13). And also, because it is a Beta-2 agent, clen can decrease insulin sensitivity (2), unfortunately.


    Clen is a very effective repartitioning agent, and this is what it’s most often used for in athletic circles. It will increase your ratio of Fat Free Mass (FFM) to Fat Mass, by decreasing your Fat and possibly increasing your FFM (3). Lets quantify that a bit:

    In one study, horses given a semi-reasonable dose of clen (slightly over 1mcg/lb x2 a day) and excercised for 20mins, 3x a week ( I suppose they were Mentzer disciples) had significant decreases in %fat (-17.6%) and fat mass (-19.5%) at week 2, which was similar to Clen given to horses who didn’t excercise; in contrast, the excercised group had a different FFM response, which significantly increased (+4.4%) at week 6 (3). Week 6! Here’s a chart illustrating the changes in % of BodyFat experienced in the various test groups, followed by a chart showing the increase in Fat Free Mass experienced by the same groups:


    Changes in percent body fat (%fat) over time in clenbuterol and exercise (ClenEx; A), clenbuterol only (Clen; B), exercise only (Ex; C), and control (Con; D) groups. Means with different letters (a and b) are significantly different.



    Changes in fat free mass (FFM) over time in ClenEx (A), Clen (B), Ex (C), and Con (D). Means with different letters (a-c) are significantly different.

    I think those charts should clearly illustrate the repartitioning effects of Clen, even though it is known that it’s effects on animals are typically much more dramatic than in humans….There’s still no doubt about it, in my mind…Clen will help you lose fat and gain muscle.
    So Let’s re-examine that first point I made: Clen vs. clen+excercise produce roughly the same results for the first 2 weeks! This tells me that the 2 weeks on and 2 weeks off schedule for clen dosing is far from optimal, and if you want the quasi-anabolic effect from the clen, it’ll take more than 2weeks on (6 weeks apparently). In addition, since clen alone is similar to clen+excercise for those first 2 weeks...why would you ever use a 2on/2off protocol? Keep in mind that animal responses to beta-agonist/antagonists differ a bit from ours…but I’m sure that you get the idea that 2on/2off is not a great dosing protocol. If I were using clen, I’d be using it for 6-12 weeks at a time, if I expected to get maximum results from it, but certainly, the most dramatic effects on fat loss appear to be in weeks 1-2. The reasons for the further increase in FFM around week 6 despite no changes in %fat or fat mass is not easily explained….. It might be that clenbuterol can increases FFM through another nonreceptor-mediated pathway, which would be very good for us, since the anabolic effects would also be applicable in humans, despite the fact that animals often respond more dramatically to beta-agonist/antagonists, due to receptor properties.. However, clenbuterol is highly lipophylic and can also enter muscle tissue (12), so that could indicate a possible mechanism of work. Maybe that would explain the significant increase in FFM of 13 kg in at 8 wks in the study? Certainly, muscle protein synthesis (MPS) must be a part of it, since clen will increase MPS in your body (17)…But it has even been speculated that the growth-promoting effect of clenbuterol may be specific to muscle and that the drug may act in a not-yet-understood manner which circumvents (!) the physiological mechanisms responsible for the control of muscle growth (13). This may mean that clenbuterol can help blast you past “sticking points” in your training by circumventing the usual mechanisms by which anabolism is experienced! It is of note that both muscle composition and fibre size has been shown to increase with administration of clen (14).

    In any case, Clearly the results you want to reproduce for yourself are those to be gained by clen + exercise, for 6 weeks or more. This type of dramatic anabolic effect hasn’t been confirmed in human studies (8), but the anabolic effects of clen in animal (specifically equine and rodent) studies are clearly quite astounding.


    Now that I told you how great clen is, I’ll tell you how to take it…

    Clen has a biphastic elimination, which means that it is technically reduced in your body in 2 different stages. This isn’t particularly important, as a recent study has shown that for most intents and purposes, clen concentrations in the body decline with a ½ life (approximately) equivalent to 7-9.2hours and again up to as much as 35 hours later(4)(5). If you’re really interested, though, clen technically declines biphastically at 10 and then 36 hours. But really, in our little world, where we use ½ life to tell us when to take our next dose, who the hell is going to take clen, then a dose 10 hours later, then a dose 36 hours later? We’ll stick with the earlier 7-9 hour ½ life for dosing purposes, and take our clen every 3.5-4.5 hours that we’re awake, stopping early enough to still be able to get to bed. Clen can, in some people, cause insomnia (and as with all stimulants, can cause anxiety in some). Recently, it’s become popular to take a whopping dose of clen in the morning, and that’s it for the day. There’s nothing wrong with this, I guess, but I’d rather not go through that kind of roller-coaster of sweating and shaking until it wore off.
    Based on it’s rate of elimination from the body, and how much is usually needed to be effective for athletes, my recommendations are the same for both men and women. You’ll need to take 20mcgs upon rising, and then repeat that same dose again later in the day, and then once again in that day (if you find you can tolerate the effects). So you’ll start with 20mcgs, and then repeat that dose 2 more times that same day if you can tolerate it (side effects will determine this…hand shaking, sweating, etc…classic stimulant sides). Then you can start increasing the dose gradually. Personally, I wouldn’t work my way up to more than 200mcg/day. 60-120mcg/day is an average dose. And keep your Blood Pressure at (or under) 140/90, while on clen, just to be safe. If you go over that, lower the dose. You’ll also want to know your body temperature, upon rising, for the week before you start taking your clen, and then monitor it (again, as soon as you wake up) throughout your clen regimen. When it returns to the level it was at before you began taking the clen, you’ll need to start taking your Benadryl or Ketotifen, as the decrease in Body Temperature back to original levels indicates the thermogenic effect is beginning to decline.

    Clenbuterol can also cause a downregulation in testicular androgen receptors and in pulmonary, cardiac and central nervous system beta-adrenergic receptors(6.)…possibly making steroids less effective (if there is androgen receptor downregulation elsewhere as well, then it's highly probable) while you are on clen; but definitely making clen less effective as time goes on and you keep taking it. To counteract this, you can take some ketotifen every 3rd or 4th week that you remain on clen. It’s a prescription anti-histimines, so it’ll make you drowsy (take before bedtime). Basically, the way this works is to reduce beta-2 receptor activity, and restore receptor function (15).

    Another option, if you are worried about receptor downgrade, is taking Benadryl, at around 50-100mgs/night before bed (every 3rd week or so, for that week). Benadryl is sold as an anti-histimine in the United States, and/or a sleep aid elsewhere in the world. However, Beta receptors are embedded in the cell's outer phospholipid membrane. The stability of the membrane has a lot to do with the proper function of the receptors. Methylation of the phospholipids is stimulated by the binding of beta agonists to their receptors. Methylated phospholipids are foreign to the body, and when the body recognizes tham as foreign, it breaks them down with phospholipase A2. This changes the structure of the outer membrane which results in desensitizaton of the beta receptors. On the other hand, agents that inhibit phospholipase A2 slow desensitization.

    Cationic ampiphylic drugs are known for their ability to inhibit phospholipase A2. Benadryl (diphenhydramine) is a cationic ampiphylic drug.

    Ergo, Benadryl slows desensitization of Beta receptors (i.e. Upgrades them) by inhibiting phospholipase A2, which is the enzyme that breaks down methylated phospholipids, and this action in turn keeps the phospholipid membrane stable, and thus keeps the receptors functioning properly. (7). This will allow you to use clen for much longer and it'll still have the same effects. Also, since Benadryl is an anti-histamine, and histamines have a direct effect on beta-adrenoreceptors (not just Beta-2’s but all of them), using an anti-histamine will have a direct effect on reducing beta-receptor stimulation (16), and thus upregulating your beta-receptors.

    Since we’re speaking about beta-receptors and upregulation, here, let me address the claim that you can use ephedrine (or the ECA stack), alternating with clen, in order to avoid receptor downgrade. I’m not sure where this rumor came from, but it is totally incorrect.

    To dispel this myth, lets examine ephedrine for a second. Remember when I said that using clenbuterol to stimulate the beta-2 receptors is like hitting a tack with a hammer? Well, Ephedrine is like a sledge-hammer, it hits the beta-2's and everything around them. Thats because it's not selective, but rather it stimulates other receptors to a great degree as well.

    Anyway, one of those receptors that ephedrine hits is the Beta-2 (yeah...the same one as Clen). As you can see from the graph below(ephedrine is represented by the the solid circles), it reduced Beta-2-AndrenergicReceptor (what we call, in laymens terms, the "Beta-2 receptor") levels to 32% of the control level after 24 hours. Read this again:

    Ephedrine, in this study, reduces Beta-2 receptor levels to 32% of control after 24 hours.

    (see the solid circles in this graph represent ephedrine)





    Granted, it's not perfect, it's not in vivo, etc...but there's no denying that ephedrine will downregulate beta-2 receptors....ergo you will not be able to use it on the weeks inbetween your clen to upgrade your receptors.


    Also, bear in mind that clen isn’t great for your heart, and can cause some issues there (enlargement of ventricles, etc…) but most studies showing clen to cause heart problems are with animals, and even though the dosing is almost similar to what humans take (in some studies it’s within the range of what would be double of a large human dose...) it’s important to remember that animals have more beta-2 receptors and they cause certain event chains that humans’ beta-2 receptors may not. Clen causes cardiac hypertrophy and cardiac necrosis (cell death)to some degree, in some cases. Again though, many studies showing the more significant, possibly irreversible, heart problems are with mg dosing. We humans take clen in mcg doses.

    If we want to duplicate those “theraputic” levels of clen seen in the more conservative studies, we’d still be taking just over 1mcg/lb of bodyweight, twice a day. I’d suggest a bit less than half of that dose, however, even if just to avoid cardiac complications.

    Performance issues with clen also vary. Some studies show reduced exercise (cardiovascular) performance with clen (9), while some show that clen can alleviate exercise induced asthma (10)!Clearly, this compound will have different effects on different people, and I suspect that a lot of it is sports specific. Many bodybuilders claim that clen makes it difficult for them to do cardio, yet I can play a full game of rugby on it. You need to figure out how it affects you, and tailor your dose personally.

    Finally, this brings me to the issue of cramps while on clen. I don’t get them. My friends don’t get them. Most of us are athletes who use clen during the season as well as the off season, and one of my friends even claims that it gives him more “wind” (cardiovascular stamina). Take on enough water every day and you should be fine. If you’re really concerned, you can take some extra minerals and taurine, since clen depletes taurine (11) as do most if not all beta-agonists. I don’t take anything more than my usual vitamins and minerals.


    1st Graph Reference:
    ASPET Journals, Vol. 58, Issue 2, 421-430, August 2000
    Kinetic Analysis of Agonist-Induced Down-Regulation of the 2-Adrenergic Receptor in BEAS-2B Cells Reveals High- and Low-Affinity Components
    Bruce R. Williams, Roger Barber, and Richard B. Clark

    2nd set of Graph references:
    J Appl Physiol 91: 2064-2070, 2001; 8750-7587/01
    Chronic administration of therapeutic levels of clenbuterol acts as a repartitioning agent
    Charles F. Kearns1, Kenneth H. McKeever1, Karyn Malinowski1, Maggie B. Struck1, and Takashi Abe2

    Other References:
    (1)Int J Obes Relat Metab Disord. 1994 Jun;18(6):429-33.
    (2)Am J Physiol Endocrinol Metab. 2002 Jul;283(1):E146-53
    (3)J Appl Physiol. 2001 Nov;91(5):2064-70
    (4)J Anal Toxicol. 2001 May-Jun;25(4):280-7.
    (5)J Pharmacobiodyn. 1985 May;8(5):385-91.
    (6)J Anim Physiol Anim Nutr (Berl). 2004 Apr;88(3-4):94-100
    (7)Prog Clin Biol Res. 1981;63:383-8
    (8)Ann Pharmacother. 1995 Jan;29(1):75-7
    (9)Med Sci Sports Exerc. 2002 Dec;34(12):1976-85.
    (10)Respiration. 1987;51(3):205-13.
    (11) Adv Exp Med Biol. 1996;403:233-45
    (12) Food Addit Contam 13: 259-274, 1996
    (13) Biochem J. 1989 Jul 1;261(1):1-10.
    (14) Biosci Rep. 1987 Feb;7(2):143-9.
    (15) Z Erkr Atmungsorgane. 1990;175(3):141-6
    (16) Comp Biochem Physiol C. 1989;92(1):143-8.
    (17) Biosci Rep. 1984 Jan;4(1):83-91.

  21. #21
    Machdiesel's Avatar
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    Quote Originally Posted by Dozer
    did it also say 30ml after the 200mcg meaning you would have 6000mcgs?
    I think someone found the flaw in my math, i was assumng i take 60 mcg a day, and its 60 dollars for 200 mcg, so i messed up my bad

  22. #22
    Machdiesel's Avatar
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    yea that the articel i was reffering to, what im saying is many other sites think the 3 on 3 off is good, i mean i trust this site, but its tough to make a decision when every site has a diff dosage method, u know

  23. #23
    Machdiesel's Avatar
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    also quik question, 30 ml 200 mcg bottle, if i take 60 mcgs to start a day, this bottle will be more then enough for 1 month correct??
    ill prob run week 1 60 mcgs, week 2 jump to 90(as long as side effects stay bearable) then jump to 120 for the remainder, does that look about right>
    Last edited by Machdiesel; 04-25-2005 at 12:38 AM.

  24. #24
    Machdiesel's Avatar
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    bump

  25. #25
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    I would say 2 weeks on/2 weeks off, ECA in weeks that you are off.

    Start at 40/60 mcg on day one and slowly increase by 20mcg a day until you cannot take the sides. I was using 180mcg per day. run whatever you plateau at for the remainder of the two weeks and then stop taking clen and start to run an ECA stack. then when you begin clen again in week 5 start alittle lower than where you left off, I started back up at around 140mcg.

    Be sure to take 3-5 g of taurine, potassium, and drink plenty of water. Also take the clen after morning cardio.

  26. #26
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    I pay like £25 for 100 in wales so i think thats like $40 is that any good ?

    Ive taken it twice now and on my 3rd cycle...but i take it for 6-8 weeks at a time using benadryl on the 3rd weeks then 2-3 weeks off and i never take more then 120mcg - 6 0.02 a day as soup said make sure you get **** loads of water in you that is the main thing and your potassium and taurine i get my taurine out of energy drinks like vk energy and red bull because no one seems to sell taurine tabs where im from here in wales..if you go by what people have said and use it dont abuse then you will see great results...Good luck bro and tell the ****er who said there 500 bucks to go eat **** * and die.


    Remember you can take as much drugs and supplements as you like but if you dont diet right then your wasting your money !

  27. #27
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    ight guys thanx alot, i think im gonna go with a 6 week cycle, doing benadryl the 3rd week, i think this should be sifficent enough for what im looking for, thanx for all ur help

  28. #28
    Machdiesel's Avatar
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    Can someone hit me up with a pm with a safe place to get this, i have website in mind, but wanna make sure its a good site n safe, thanx alot

  29. #29
    Machdiesel's Avatar
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    bump, also is liquid or pills better?

  30. #30
    biggen is offline Associate Member
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    wow thats expensive. look at the top right of your computer screen and click

  31. #31
    Machdiesel's Avatar
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    hahah that was the site i was referring ot with that price, but i found out that 30/ml is equal to 6000 mcgs (i saw the 200 mcg n assumed that was the same calculation as the 60 a day i need to take, my mistake, so im guessing this site would be optimal?

  32. #32
    Latinbrothie is offline Junior Member
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    Email me about where to find this stuff easily if you haven't ordered it yet. Clen is really working for me, im gonna do the straight through cycle with benadryl also. The Taurine and potassium supplements are working really well to reduce the side effects too ( 3-5 dollars each at GNC).

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