Thread: Milk Thistle? WTF
06-01-2002, 09:37 AM #1
Milk Thistle? WTF
Milk thistle? Does it really do anything for Liver toxicity? I am wondering because I think i have some growing in my yard along the fence. Just teasing on that one but anyones perspective would be greatly appreciated.
06-01-2002, 10:10 AM #2
06-01-2002, 05:48 PM #3Member
- Join Date
- Mar 2002
- New York
ulter how much do i need to take and will it help my liver agasint winni and drinking ?
06-01-2002, 07:12 PM #4
so I'm taking these milk thistles for nothing???? can someone shed some light on this??
06-01-2002, 08:23 PM #5
06-01-2002, 08:28 PM #6
bro they do help and thats a fact ,ok then so about 90?of the people on here are wrong and your right.actually ive read not heard that it works so good that it inhibits gains.
06-01-2002, 10:45 PM #7
inhibits gains????? so its bad for your muscle gains?
06-02-2002, 01:22 AM #8
06-02-2002, 04:34 PM #9
06-03-2002, 10:32 AM #10
You should take two Tyler in the morning and two at night when you're cycling.
ALA and Tyler will take care of it. Milk Thistle is more of a BB Myth than anything else. The studies on it are very weak and do not apply to using 17aa meds they are for liver protection from poison mushrooms. I posted this the other day.
BioDrugs 2001;15(7):465-89 Related Articles, Books, LinkOut
Silymarin: a review of its clinical properties in the management of hepatic disorders.
Wellington K, Jarvis B.
Adis International Limited, Auckland, New Zealand. email@example.com
The mechanisms of action of silymarin involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as alpha-amanitin. Studies in patients with liver disease have shown that silymarin increases superoxide dismutase (SOD) activity of lymphocytes and erythrocytes, as well as the expression of SOD in lymphocytes. Silymarin has also been shown to increase patient serum levels of glutathione and glutathione peroxidase. Silybin 20 to 48 mg/kg/day has shown promise as a clinical antidote to acute Amanita (deathcap mushroom) poisoning. Primary efficacy data from 3 trials which examined the therapeutic potential of silymarin in patients with cirrhosis, and included patient survival as an end-point, demonstrated that silymarin had no significant beneficial effect on patient mortality. However, upon subanalysis, silymarin 420 mg/day had a significantly beneficial effect on patient survival rate (compared with patients receiving placebo) in 1 randomised, double-blind trial in patients with alcoholic cirrhosis. Silymarin 420 mg/day was also shown to improve indices of liver function [AST, ALT, gamma-glutamyl transferase and bilirubin] in patients with liver disease of various aetiology, including those exposed to toxic levels of toluene or xylene; however, it was largely ineffective in patients with viral hepatitis. Reports of adverse events while receiving silymarin therapy are rare. However, there have been accounts of nausea, epigastric discomfort, arthralgia, pruritus, headache and urticaria. Silymarin has also been reported to have possibly caused a mild laxative effect. CONCLUSION: The antioxidant properties of silymarin (a mixture of at least 4 closely related flavonolignans, 60 to 70% of which is a mixture of 2 diastereomers of silybin) have been demonstrated in vitro and in animal and human studies. However, studies evaluating relevant health outcomes associated with these properties are lacking. Although silymarin has low oral absorption, oral dosages of 420 mg/day have shown some therapeutic potential, with good tolerability, in the treatment of alcoholic cirrhosis. Moreover, silybin 20 to 48 mg/kg/day has shown promise as an antidote for acute mushroom poisoning by Amanita phalloides; however, further studies paying attention to the amount of ingested mushroom and time elapsed before administration of treatment are needed to clarify its role in this indication. Studies in patients with the early onset of liver disease may demonstrate the liver regeneration properties that silymarin is promoted as possessing.
Drugs 2001;61(14):2035-63 Related Articles, Books, LinkOut
The use of silymarin in the treatment of liver diseases.
Saller R, Meier R, Brignoli R.
Abteilung Naturheilkunde, University Hospital Zurich, Switzerland.
The high prevalence of liver diseases such as chronic hepatitis and cirrhosis underscores the need for efficient and cost-effective treatments. The potential benefit of silymarin (extracted from the seeds of Silybum marianum or milk thistle) in the treatment of liver diseases remains a controversial issue. Therefore, the objective of this review is to assess the clinical efficacy and safety of silymarin by application of systematic approach. 525 references were found in the databases, of which 84 papers were retained for closer examination and 36 were deemed suitable for detailed analysis. Silymarin has metabolic and cell-regulating effects at concentrations found in clinical conditions, namely carrier-mediated regulation of cell membrane permeability, inhibition of the 5-lipoxygenase pathway, scavenging of reactive oxygen species (ROS) of the R-OH type and action on DNA-expression, for example, via suppression of nuclear factor (NF)-kappaB. Pooled data from case record studies involving 452 patients with Amanita phalloides poisoning show a highly significant difference in mortality in favour of silibinin [the main isomer contained in silymarin] (mortality 9.8% vs 18.3% with standard treatment; p < 0.01). The available trials in patients with toxic (e.g. solvents) or iatrogenic (e.g. antispychotic or tacrine) liver diseases, which are mostly outdated and underpowered, do not enable any valid conclusions to be drawn on the value of silymarin. The exception is an improved clinical tolerance of tacrine. In spite of some positive results in patients with acute viral hepatitis, no formally valid conclusion can be drawn regarding the value of silymarin in the treatment of these infections. Although there were no clinical end-points in the four trials considered in patients with alcoholic liver disease, histological findings were reported as improved in two out of two trials, improvement of prothrombin time was significant (two trials pooled) and liver transaminase levels were consistently lower in the silymarin-treated groups. Therefore, silymarin may be of use as an adjuvant in the therapy of alcoholic liver disease. Analysis was performed on five trials with a total of 602 patients with liver cirrhosis. The evidence shows that, compared with placebo, silymarin produces a nonsignificant reduction of total mortality by -4.2% [odds ratio (OR) 0.75 (0.5 - 1.1)]; but that, on the other hand, the use of silymarin leads to a significant reduction in liver-related mortality of-7% [OR: 0.54 (0.3 - 0.9); p < 0.01]. An individual trial reported a reduction in the number of patients with encephalopathy of -8.7% [p = 0.06). In one study of patients with cirrhosis-related diabetes mellitus, the insulin requirement was reduced by -25% [p < 0.01). We conclude that available evidence suggests that silymarin may play a role in the therapy of [alcoholic) liver cirrhosis. Silymarin is has a good safety record and only rare case reports of gastrointestinal disturbances and allergic skin rashes have been published. This review does not aim to replace future prospective trials aiming to provide the 'final' evidence of the efficacy of silymarin.
There just doesn't seem to be any evidence it works for what we need it for.
06-03-2002, 10:42 PM #11
thanks man, answered that question for me. appreciate it
06-04-2002, 12:31 PM #12Junior Member
- Join Date
- Sep 2001
Man if you don't want to take milk thistle "cause it is useless" then what ever floats your boat. It really does not matter what you take to help your liver cause it is not gonna make it 100% safe from gear. In any case if you are taking vitamin E every day at 400iu then you are also helping your liver out alot. I do all i can for mine when i gear.
06-04-2002, 01:52 PM #13Junior Member
- Join Date
- Apr 2002
Thre was an article in Muscular Developement mag. about how milk thistle could hurt gains. I believe it was the Jan or Feb 2002 edition. It has been a while since I read the article but I believe it said something like milk thistle can block protien from getting into muscle cells. Some shit like that. Anyway I don't use milk thistle anymore...ALA is much better IMO.
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