would taking nolva mid cycle be the same as taking an arimidex?

**thesecretuser** · 03-07-2014, 05:21 PM

hey guys just wondering if nolva would aid with high blood pressure, i know an ai is a preventer which basically prevents estrogen from even ocurring while nolva is simply an estrogen blocker which would only be blocking existing estrogen.
my last cycle was a 7 weeks of test 400 and i get some pretty bad headaches through out the cycle and my heart kinda started beating pretty fast ocasionally, so would taking nolva instead of arimidex help me out with thew high blood pressure?

**kelkel** · 03-07-2014, 05:41 PM

No. Stick with arimidex and pull BW mid cycle to see if you are managing it properly.
Also check your RBC's. Blood can thicken on cycle (polycythemia) and cause serious issues.

**thesecretuser** · 03-07-2014, 06:01 PM

will do kelkel, thanks for the insight.

**Docd187123** · 03-07-2014, 06:21 PM

Originally Posted by kelkel

no. Stick with arimidex and pull bw mid cycle to see if you are managing it properly.
Also check your rbc's. Blood can thicken on cycle (polycythemia) and cause serious issues.

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X2

**thesecretuser** · 03-07-2014, 07:32 PM

Originally Posted by docd187123

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X2

x3..

**DiyGynoSurgeon** · 03-07-2014, 09:13 PM

Manage it with adex or aromasin , I also like to take an aspirin every night while on cycle and celery seed extract and flaxseed oil, buy a personal blood pressure device and check daily to keep you in the know

**Docd187123** · 03-08-2014, 03:56 AM

Originally Posted by DiyGynoSurgeon

Manage it with adex or aromasin, I also like to take an aspirin every night while on cycle and celery seed extract and flaxseed oil, buy a personal blood pressure device and check daily to keep you in the know

I wouldn't just advise someone to jump on daily aspirin regimen without first consulting their doctor. Doing so puts you at an increased risk for gastric bleeding, hemorrhagic stroke, and a small increase in the risk of hypertension (the issue you're trying to solve in the first place in this context).

**Bonaparte** · 03-08-2014, 12:16 PM

Originally Posted by Docd187123

I wouldn't just advise someone to jump on daily aspirin regimen without first consulting their doctor. Doing so puts you at an increased risk for gastric bleeding, hemorrhagic stroke, and a small increase in the risk of hypertension (the issue you're trying to solve in the first place in this context).

Those aren't issues with an enteric-coated baby aspirin (what most people use).

**Docd187123** · 03-08-2014, 01:19 PM

Originally Posted by Bonaparte

Those aren't issues with an enteric-coated baby aspirin (what most people use).

According to my readings even enteric coated baby aspirin causes these problems although not as common.

This is my understanding:

Enteric coated baby aspirin works by presenting a polymer barrier which is resistant to the acidic environment in the stomach. Rather it breaks down easily in more alkaline environments such as in the small intestine. Aspirin works by

Aspirin's actions begin with its effects on two important enzymes, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Think of COX-1 as a "housekeeping" enzyme because it's present in many tissues, where it helps maintain various functions. For the most part, COX-1 does its job by stimulating a family of chemicals called prostaglandins.

A particular prostaglandin (thromboxane A2) is the "glue" that makes platelets stick together and form clots. By inhibiting COX-1, aspirin interrupts this chain of events and reduces the risk of heart attacks. But since platelets also trigger the "good" clots that stanch bleeding from injured tissues, aspirin increases bleeding, whether from a shaving nick or a serious wound.

Prostaglandins in the stomach stimulate gastric blood flow and the production of acid-neutralizing bicarbonate and protective mucus. By inhibiting COX-1, aspirin reduces prostaglandins that protect the stomach, increasing the risk of bleeding and ulcers.

Prostaglandins also help regulate kidney function and blood flow. By inhibiting COX-1, aspirin can reduce these protective chemicals, sometimes raising blood pressure or reducing kidney function, especially in the elderly or in patients with kidney disease.

If COX-1 is a housekeeping enzyme, COX-2 is more of a troubleshooter. Instead of hanging around in healthy cells and tissues, it gets fired up in response to assaults such as infection and inflammation. COX-2 generates chemicals that trigger fever and pain; drugs that inhibit COX-2 do a nice job of reducing pain and lowering high temperatures. But COX-2 is not all bad; it also produces prostacyclin, a chemical that widens arteries and fights blood clotting. Drugs that inhibit COX-2 may increase the risk of heart attack and stroke by reducing prostacyclin. That's why the selective COX-2 inhibitors rofecoxib (Vioxx) and valdecoxib (Bextra) were withdrawn from the market, while a third one, celecoxib (Celebrex) requires extreme care. And it's also why the many nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit both COX-1 and COX-2 have a mixed reputation (more on that later).

Aspirin in the stomach is only one issue. The other is

Aspirin in the stomach is not the problem; aspirin in the blood inhibits COX-1, reducing the prostaglandins that protect the stomach.

Aspirin and Your Heart: Many Questions, Some Answers - Harvard Health Publications

At least this is what I'm getting out of it?