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  1. #1
    Strongblood's Avatar
    Strongblood is offline Productive Member
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    AI vs SERMs for Controlling Estrogen

    I read somewhere that AIs like Arimidex cause bad cholesterol to rise where as SERMs do not. Has any of you ever heard of this? I've never used any SERMs, but I am interested in anything that can help keep bad cholesterol in check and lower estrogen while on cycle.

  2. #2
    Splifton's Avatar
    Splifton is offline Associate Member
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    AI's and SERMs are two radically different groups of pharmaceuticals with their own individual pharmacokinetics/dynamics. Both interact with our endogenous oestrogenic compounds, but do so in very different ways. AI (aromatase inhibitor) are a class of drugs that possess inhibitory activities on the aromatase' function which includes it's role in being the catalyst for oestrogenic hormones (testosterone >estradiol:5a-androstanedione>estrone this will also aromatize any anabolic /androgenic steroid that possess a methylat

    I was under the presumption that anastozole was relatively minor in it's alterations to your HDL/LDL levels and what alterations it did produce were unfavorable. Tamoxifin lowers your LDLs in a beneficial direction, but if you are concerned about your lipid numbers and TG/TC then anabolic/androgenic steroids in supraphysiological dosages isn't aiding in the journey either.
    Last edited by Splifton; 11-26-2015 at 08:02 PM.

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