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  1. #1
    Pheedno is offline Respected Member
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    Aromasin likely to effect lipids?

    It's been previously thought that exemestane(Aromasin ) had no negative effects on lipids since it worked at disinguaging binding affinity of estrogen, and not aiding in preventing conversion like it's "cousin" anti-e's Arimidex & Letrozole .

    Now, I have never seen a study, or blood work showing Arimidex effects lipids, but it has to be a possibilty given it's mechanism of action. It's probably not strong enough in the doses we take(or possibly up to 1mg) for it to produce a drop in HDL. I personally use L-dex specifically because femara has shown to be detrimental to maintaining a healthy HDL level.

    I recently found a caption of a study on Pubmed barley mentioning lipid effects with aromasin. I'll be doing some further research on this over the next wk or so to see if I can locate anymore finding pertaining to lipid effect from this particular AI.

    If anyone runs across any material which might be helpfull, please contribute.

    http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract

  2. #2
    D3m3nt3d's Avatar
    D3m3nt3d is offline AR's Whore D'Oeuvre
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    Pheedno your a very smart guy bro, but your big words give me a headache

  3. #3
    Billy_Bathgate's Avatar
    Billy_Bathgate is offline AR Vet / Retired
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    Ive yet to find anything either.

  4. #4
    Pheedno is offline Respected Member
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    This study also mentions a marginal drop in HDL with the addition of Aromasin during tamoxifen treatment

    http://www.asco.org/ac/1,1003,_12-00...0101350,00.asp


    These two stating no change, the latter even suggests an improvment in triglycerides

    http://www.asco.org/ac/1,1003,_12-00...+Breast+Cancer

    http://www.pslgroup.com/dg/1FAF8A.htm

  5. #5
    Pheedno is offline Respected Member
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    From what I gather, the majority of readings find no adverse effects, but theirs still a slight possibility that effects on HDL can occur. Individualistic indeed.

    All in all though, as far as case studies comapred between the inhibitors and inactivator, Aromasin certainly shines through.

  6. #6
    Billy_Bathgate's Avatar
    Billy_Bathgate is offline AR Vet / Retired
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    On a personal level, Ive noticed much better results.

    However, its hard to really control that observation so I dont quite draw a conclusion from that.

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