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  1. #1
    dwaynewade's Avatar
    dwaynewade is offline Senior Member
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    Post ladies... here's some info on breast cancer & i-gf

    Not to scare, rather inform... there aren't many ladies here using i-gf but many do use GH which also produces these growth factors so... read up !

    Abstract
    Breast cancer is a leading cause of cancer death of women in the U.S. today. Members of the family of insulin -like growth factors (IGFs) are proposed to play a major role in the development and subsequent uncontrolled proliferation of breast cancer cells. Insulin-like growth factor-I (IGF-I) is known to be a potent mitogen for mammary epithelial cells. IGF-I acts by binding to cell surface receptors, thereby stimulating a cascade of events leading to cell division. In the interest of interrupting the effect of IGF-I on cancerous mammary epithelial cells, an understanding of how IGF-I behaves in the presence of other extracellular components is needed. This study examines the IGF-I response of SV40-IGF-I, an immortalized bovine mammary epithelial cell line which secretes IGF-I constitutively.


    The microphysiometer allows real-time sampling of cellular activity by measuring the excretion of protons from a sample of cells stimulated by IGF-I binding. The contributions of other factors in enhancing or suppressing stimulation can be compared by examining the pH response of cells exposed to IGF-I in the presence of these factors. We present data showing the stimulatory effect of IGF-I in a dose dependent manner on the SV40-IGF-I cell line.


    In addition, we compare IGF-I stimulation with stimulation by long R3IGF-I, a substituted analogue of IGF-I having a reduced binding affinity for the IGF binding proteins. We examine the effect of insulin-like binding protein-3 (IGFBP-3) both in the presence and absence of IGF-I, finding no IGF-I independent effect in the rapid binding experiment and no effect on stimulation of IGFBP-3 pre-incubated cells by subsequent IGF-I challenge. This is of particular interest due to recent work demonstrating an IGF-independent IGFBP-3 response in a number of cell lines. Binding studies to correlate with the rapid binding stimulation show binding of the IGFBP-3 molecule with high affinity to a small number of surface receptors on the SV40-IGF-I cell.


    Analysis of the extracellular environment and the components contributing to the binding of IGF-I to the cell membrane receptor will provide information for the development of interventions to slow or interrupt the process of IGF-I binding and therefore cancer growth. Optimization of the Cytosensor(r) Microphysiometer System for the (transfected) SV40-IGF-I and the (parental) MAC-T cell lines was achieved to continue comparison studies of autocrine and paracrine stimulation of bovine mammary epithelial cells by IGF-I.


    This work was supported by the Whitaker Foundation Biomedical Engineering Grant.

  2. #2
    JohnnyB's Avatar
    JohnnyB is offline AR-Hall of Famer / Retired
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    I posted it in your other post but I'll say it here again.

    Patients with cancer have been found to have high levels of IGF-1, the simulation of IGF-1 or a rise in their levels, does not cause cancer, it mutates the cell that already have the cancer in them. This is why drugs that treat breast cancer lower IGF-1 levels.

    So to make it clear for others that read this, IGF-1 does not cause cancer, but it will cause it to grow faster, so if you have cancer or a family history DO NOT use AAS/HGH/LR3 IGF-1, because they all rise IGF-1 levels, which can cause the cancer to grow.

    JohnnyB

  3. #3
    dwaynewade's Avatar
    dwaynewade is offline Senior Member
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    tx JohnnyB

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