Anabolics
Search More Than 6,000,000 Posts
Results 1 to 10 of 10
  1. #1
    JohnnyB's Avatar
    JohnnyB is offline AR-Hall of Famer / Retired
    Join Date
    Apr 2002
    Location
    Califas
    Posts
    9,265

    LR3 IGF-1 in small intestines

    This is good news for those worried about getting a gut from LR3 IGF-1.


    The role of insulin-like growth factors in small intestinal cell growth and development.

    MacDonald RS.

    Nutritional Sciences Program, University of Missouri, Columbia, USA. macdonaldr@missouri.edu

    IGF-I and IGF-II receptors are expressed in the small intestine of mammalian species, as are the genes to synthesize both peptides. IGF binding proteins are also expressed in the intestine. IGF-I and IGF-II mRNA are highest in fetal and newborn tissues and decrease with age. IGF-I mRNA is present in the adult small intestine, and is associated with the submucosal regions and crypt cells. IGF-I and IGF-II receptor binding to the small intestine is higher in newborn animals and decreases with age. Both receptors are more concentrated in the crypt than villus regions, but IGF-II binding is higher than IGF-I in all regions. IGF-I receptors are associated with the submucosal region of the small intestine, whereas IGF-II receptors are more abundant in the mucosal cells. Administration of IGF-I either orally or by osmotic pump generally has no affect on small intestinal weight or length, but does increase mucosal cellularity. LR3-IGF-I administration by osmotic pump affects the small intestine similarly to IGF-I, although with a higher potency. In the few studies in which IGF-II was administered, increased gut mass was observed in adult rats, but not newborn rats or pigs. Significant effects on mucosal expression of disaccharidases was achieved with either oral or subcutaneous IGF-I or oral IGF-II. Administration of IGF in models of intestinal hypertrophy and atrophy are also reviewed.

    JohnnyB

  2. #2
    longhornDr's Avatar
    longhornDr is offline Member
    Join Date
    Feb 2003
    Location
    Galveston Texas
    Posts
    528
    What dosages were used? Would be interesting to see how they compare to the amounts being recommended for bodybuilding purposes.

  3. #3
    JohnnyB's Avatar
    JohnnyB is offline AR-Hall of Famer / Retired
    Join Date
    Apr 2002
    Location
    Califas
    Posts
    9,265
    I'll go back and see if I can get the full text, but this is going to blow your mind I did see 1 study that has a high dose of LR3 IGF-1. Higher then I've heard of anyone using.

    JohnnyB

  4. #4
    jbigdog69's Avatar
    jbigdog69 is offline Banned
    Join Date
    Mar 2004
    Location
    Euphoria
    Posts
    2,129
    Ok Johnny I'm not a brain surgeon Dog. What does all this mean?? Are my intestines gonna grow or not grow. Thanks

  5. #5
    Join Date
    Dec 2003
    Posts
    3,145
    I think it's really good info, but I'm trying to find a study I saw before that mentioned differential expression of IGF receptor types comparing humans, rats, and pigs. It showed humans have a higher proportion of IGF-1 receptors on the intestines, in general, than did rats, but pigs were similar? It also mentioned the same type of differences on the spleens of the three.

    If you can dig up that other study using high dose LR3, that'd be great.

    I saw a study similar to this where they were treating rats with IGF-1 and testing for enhanced nutrient uptake, because of IGF-1 binding in the intestines, which it did increase. I'll look for these studies.


    basically, the study is saying, in rats, that IGF-1 does not cause increased intestinal mass but does cause increased mucosal cell turnover, whereas IGF-II does increase intestinal mass. Keep in mind that GH will also increase IGF-II levels and that the intestines themselves have GH receptors too.

  6. #6
    JohnnyB's Avatar
    JohnnyB is offline AR-Hall of Famer / Retired
    Join Date
    Apr 2002
    Location
    Califas
    Posts
    9,265
    I've got 1 on wound healing with LR3 IGF-1, it's 16 pages so I'll read it during spring break, then post the abstract.

    JohnnyB

  7. #7
    Mr. Sparkle's Avatar
    Mr. Sparkle is offline Slinabolic Vet / Retired
    Join Date
    Aug 2002
    Location
    Lovin Alba's butt
    Posts
    3,008
    Wow this is some good info. thanks once again!

  8. #8
    powerlifter's Avatar
    powerlifter is offline Anabolic Member
    Join Date
    Feb 2004
    Posts
    3,651
    Nice post Bro !!!

  9. #9
    flexshack is offline Member
    Join Date
    Sep 2001
    Posts
    749
    Quote Originally Posted by JohnnyB
    I've got 1 on wound healing with LR3 IGF-1, it's 16 pages so I'll read it during spring break, then post the abstract.

    JohnnyB
    spring break? what are you in school still? lol or maybe not??

  10. #10
    JohnnyB's Avatar
    JohnnyB is offline AR-Hall of Famer / Retired
    Join Date
    Apr 2002
    Location
    Califas
    Posts
    9,265
    Quote Originally Posted by flexshack
    spring break? what are you in school still? lol or maybe not??
    Far from it, but I'm going out of town with my family so I'll get some time to read

    JohnnyB

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •