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Onset of effects of testosterone treatment and time span until maximum effects are ac

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by , 04-05-2012 at 09:28 PM (442 Views)
Onset of effects of testosterone treatment and time span until maximum effects are achieved


Objective Testosterone has a spectrum of effects on the male organism. This review attempts to determine, from published studies, the time-course of the effects induced by testosterone repla***ent therapy from their first manifestation until maximum effects are attained.

Design Literature data on testosterone repla***ent.

Results Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, with no further increments expected beyond. Changes in erections/ejaculations may require up to 6 months. Effects on quality of life manifest within 34 weeks, but maximum benefits take longer. Effects on depressive mood become detectable after 36 weeks with a maximum after 1830 weeks. Effects on erythropoiesis are evident at 3 months, peaking at 912 months. Prostate-specific antigen and volume rise, marginally, plateauing at 12 months; further increase should be related to aging rather than therapy. Effects on lipids appear after 4 weeks, maximal after 612 months. Insulin sensitivity may improve within few days, but effects on gly***ic control become evident only after 312 months. Changes in fat mass, lean body mass, and muscle strength occur within 1216 weeks, stabilize at 612 months, but can marginally continue over years. Effects on inflammation occur within 312 weeks. Effects on bone are detectable already after 6 months while continuing at least for 3 years.

Conclusion The time-course of the spectrum of effects of testosterone shows considerable variation, probably related to pharmacodynamics of the testosterone preparation. Genomic and non-genomic effects, androgen receptor polymorphism and intracellular steroid metabolism further contribute to such diversity.