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  1. Dr Mariano posts - sleep, the mind

    by , 09-10-2012 at 04:03 PM

    Excessive sleep, inability to motivate one's self are two of several symptoms that occur due to excessive pro-inflammatory signaling.

    Depression is an illness that at its heart is a pro-inflammatory condition. So are heart disease, diabetes, irritable bowel disease, allergies, and asthma.

    These days, I generally do as thorough immune system evaluation, in addition to a ...
    Tags: dr mariano
  2. Dr Mariano posts - some basics

    by , 09-10-2012 at 04:00 PM
    I prefer fasting glucose to be between 93-100 so long as there is intact gluconeogenesis and minimal insulin resistance.

    Testosterone cypionate at 100 mg a week should result in good trough levels of testosterone - around 650 ng/dL. If it is less, then perhaps the half-life of testosterone cypionate is short and a dose adjustment needs to be done.

    Ideally, from my point of view, TSH should be below 1.0, preferably between 0.03 to 0.5. Not everyone can tolerate this ...
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  3. Dr Mariano posts - inflammation, diet

    by , 09-10-2012 at 03:26 PM
    What are the top 5 or 10 things that everyone can do to decrease inflammation?

    Not in any one particular order:

    • Optimize nutrition - including eating a high nutrient density diet like a traditional diet.
    • Getting a good night sleep.
    • Regular exercise. Three hours a week is plenty.
    • Activities which reprogram brain structure and circuitry to reduce stress and inflammation - including meditation, yoga, tai-chi, mindfulness therapy,
  4. Dr Mariano posts - gastrointestinal, IBD

    by , 09-10-2012 at 03:23 PM

    As far as I know, there is no specific diet for patients with Inflammatory Bowel Disease (IBD, e.g. Ulcerative Colitis, Crohn's Disease) that is going to be a therapeutic and effective in treating the disease. In general, I don't tell my patients to avoid Legumes.

    Some considerations:

    The answer for any particular individual is: It depends on many factors. These foods may need to be considered ...
  5. Pregnenolone study done on people with schizophrenia

    by , 08-29-2012 at 01:34 AM
    Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia

    Christine E Marx


    The neurosteroid pregnenolone and its sulfated derivative enhance learning and memory in rodents. Pregnenolone sulfate also positively modulates NMDA receptors and could thus ameliorate hypothesized NMDA receptor hypofunction in schizophrenia. Furthermore, clozapine increases pregnenolone in rodent hippocampus, ...
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