Originally Posted by
Vettester
Well, not sure that I can school anyone on this subject, but I can speak a little bit about personal experiences, and what I believe is some of the reasoning behind it for maybe giving it consideration.
Like I mentioned, I pretty much had my Adex dialed in on my my protocol at .25mg x 2/wk, which complimented my 120mg/wk of cyp an 250iu x 3/wk of HCG protocol. As a maintenance dose, I could pretty much count on it to stabilize my E2 at/around my desired level. At the first of the year, my E2 was at 23pg, I believe that was the Labcorp sensitive assay (whatever the ranges are on that). After switching to SubQ, my E2 dropped to 18pg with the same assay after just a couple of months. If anything, If there were any +/- variances, I would normally see it increase just slightly, which I could then tweak my AI protocol slightly if needed for a short period of time. Never had I seen a 5 point drop in a few months on such a low dosage of AI.
From there, I discontinued my AI protocol, and even at this point my E2 is currently just in the 20's, and I attribute the slight increase to titrating my cyp dosage up a bit back in June. I just recently started a blast of 360mg of test, and 360mg of deca (both SubQ BTW), and I will run E2 labs here shortly to see the effects. I am actually looking to get my E2 up in the high 20's/low 30's for a bit, as I tend to have better physical and psychological results when in that range.
As far as why the subcutaneous application is more effective over IM with E2 control ... I feel it probably has to do with the absorption rate of the medication is going to be slower in the adipose tissue due to the blood supply not being as abundant with what you would see in the case of administering via IM. In short, the slower release into the system would help reduce some of the sudden onset of spikes associated with the peak life and half life of exogenous test, therefore potentially controlling the higher rate of downstream conversion to E2. That's just my take on it, but there maybe some conclusive scientific studies that illustrate it much differently. GD is a member that is quite articulated on this subject, so he maybe able to shed some additional insight.